Biological attempts at disc regeneration are promising; however, disc degeneration is closely related to other predisposing factors such as alteration of disc height, intradiscal pressure, load distribution, and motion. The restoration of the physiological status of the affected spinal segment is thus necessary prior to attempts at disc regeneration. Dynamic stabilization systems now offer the potential of a mechanical approach to intervertebral disc regeneration. The authors used decompression and placement of the BioFlex dynamic stabilization device to treat a young male patient with disc degeneration. This patient underwent follow-up, and he was found to gradually improve both neurologically and radiographically. On MR imaging performed 1 year postoperatively, he had an increase in disc height and disc rehydration. This case and the concept of disc rehydration are presented in this paper.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3171/2010.5.SPINE08418 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multidisciplinary unravelling Cogan's syndrome post-C-section: insights into diagnosis, treatment and a possible identified new trigger.
BMJ Case Rep
December 2024
Department of Otorhinolaryngology and Head and Neck Surgery, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany
We present a case series consisting of three female patients in their 30s with presumed autoimmune uveitis resembling Cogan's syndrome following caesarean sections (C-sections) with severe intraoperative bleeding and the use of chitosan-tamponade, exhibiting a combination of varying ocular and auditory symptoms postoperatively. Our patients displayed a range of inflammatory ocular changes, including stromal keratitis, panuveitis, retinal infiltrates, haemorrhages, optic disc swelling, and intraretinal and subretinal fluid, along with otalgia and hearing loss, consistent with typical and atypical Cogan's syndrome. Treatment involved systemic corticosteroids, resulting in variable outcomes.
View Article and Find Full Text PDFClinico-pathologic correlation in ocular sarcoidosis.
Am J Ophthalmol Case Rep
December 2024
Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Purpose: This case describes the unique course and management of a patient with progressive, refractory multi-system sarcoidosis that initially presented with ocular and dermatologic findings.
Observations: A 47-year-old male presented with acute anterior uveitis and was found to have simultaneous inflammation of his skin at a tattoo site. Diagnosis of ocular sarcoidosis was confirmed through skin biopsy.
A Comprehensive Study of Bacterial Etiological Agents in Sterile Body Fluids and Antimicrobial Susceptibility Patterns Among Hospitalized Patients at an Academic Medical Center in India.
Cureus
October 2024
Department of Microbiology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Article Synopsis
- Background: Sterile body fluids should be free of microbes, but bacterial presence can cause serious infections, making quick detection and identification of pathogens vital for patient recovery.
- Objective: The study aimed to evaluate the occurrence of bacterial infections in various sterile body fluids from hospitalized patients, focusing on understanding antimicrobial resistance and identifying specific beta-lactamase producers among bacterial isolates.
- Results: In the study, 180 sterile fluid samples were tested, with 17.77% being culture-positive, predominantly isolating gram-negative bacteria, which showed a high resistance to certain antibiotics like cefoperazone-sulbactam while exhibiting sensitivity to gentamicin and fosfomycin. *
Drug retention after intradiscal administration.
Drug Deliv
December 2024
Department of Orthopedics, University Medical Center Utrecht, Utrecht, The Netherlands.
Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics.
View Article and Find Full Text PDFAllogenic bone marrow-derived mesenchymal stromal cell-based therapy for patients with chronic low back pain: a prospective, multicentre, randomised placebo controlled trial (RESPINE study).
Ann Rheum Dis
October 2024
INSERM U 1183, Institute for Regenerative Medicine and Biotherapy, Montpellier, France
Article Synopsis
- The study aimed to compare the effectiveness of an intradiscal injection of allogeneic bone marrow mesenchymal stromal cells (BM-MSCs) to a sham placebo in chronic low back pain patients.
- 114 participants were randomly assigned to receive either the BM-MSC injection or a placebo, and outcomes were measured over 12 months using pain and disability scales, along with MRI assessments.
- The results showed no significant difference in effectiveness between the BM-MSC and placebo groups after 12 months, although the procedure was deemed safe with no serious adverse events reported.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!