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[Neurocryptococcosis waiting to be diagnosed].
Ann Biol Clin (Paris)
September 2024
Service d'Hématologie Biologique, Hôpital Universitaire Pitié-Salpêtrière, 75013 Paris, France.
Neurocryptococcosis is a severe neurological complication of Cryptococcus neoformans infections, primarily affecting immunocompromised individuals. This report describes the case of a 53-year-old man with no known medical history who experienced severe headaches and vomiting while on a business trip to Pakistan. He was given preventive antibiotic therapy, followed by a combination of sulfamethoxazole and trimethoprim for suspected toxoplasmosis.
View Article and Find Full Text PDFDiabetes Mellitus Type 2 as a Risk Factor and Outcome Modifier for Cryptococcosis in HIV Negative, Non-transplant Patients, a Propensity Score Match Analysis.
Curr Microbiol
October 2023
Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, 12700 E. 19Th Avenue, Mail Stop B168, Aurora, CO, 80045, USA.
Article Synopsis
- * A study comparing HIV-negative, non-transplant patients found that those with DM2 had a higher likelihood of cognitive dysfunction when afflicted with cryptococcosis, but similar rates of mortality and other severe outcomes compared to those without DM2.
- * It’s rare for DM2 to be the only risk factor for cryptococcosis, and other factors like kidney disease and immune dysfunction also play a role in increasing the risk among patients with DM2.
Disseminated Cryptococcus infection presenting as lytic skeletal lesions suggesting bony metastatic disease.
Skeletal Radiol
October 2024
Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, H-10, New York, NY, 10065, USA.
A 76-year-old male diagnosed with sarcoidosis presented with atraumatic left anterior knee pain. Initial imaging of the left lower extremity revealed an eccentrically-based lytic lesion in the mid-distal femur with cortical erosion and an additional lytic lesion in the proximal tibia. Magnetic resonance imaging (MRI) demonstrated an aggressive lesion in the proximal tibia with surrounding marrow edema, cortical breach, and erosion into the distal patellar tendon.
View Article and Find Full Text PDFCryptococcosis among HIV negative liver disease patients: Epidemiology, underlying conditions, antifungal susceptibility profile from tertiary care hepatobiliary center.
Indian J Med Microbiol
November 2023
Department of Microbiology, Institute of Liver and Biliary Sciences, New Delhi 110070, India. Electronic address:
Purpose: Cryptococcus neoformans is an encapsulated yeast. It is a significant pathogen among immunocompromised people with HIV & Non-HIV vulnerable populations. These conditions include cancer, corticosteroid usage, immunosuppression following sarcoidosis, organ transplantation, immunosuppressive medication, and liver cirrhosis.
View Article and Find Full Text PDFDisseminated Cryptococcosis in an Immunocompromised Patient with Altered Mental Status and a Lung Nodule.
J Community Hosp Intern Med Perspect
March 2023
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, 110 South Paca Street, Baltimore, MD, 21201, USA.
Introduction: Disseminated cryptococcosis is an opportunistic infection that commonly affects the central nervous and respiratory systems and is often fatal in immunocompromised host patients. Diagnosing disseminated cryptococcosis is challenging at times due to the nonspecific presentation, resulting in delayed treatment and increased mortality.
Case Presentation: A 48-year-old man presented with altered mental status and shortness of breath requiring intubation.
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