AI Article Synopsis
- Differential mRNA stability plays a key role in regulating virulence factors in Streptococcus pyogenes, a significant human pathogen.
- The study identifies two distinct classes of mRNA in GAS based on their stability during different growth phases and their decay patterns when specific RNases are depleted.
- Structural features of mRNA are crucial for classifying them, and a model is presented to explain the mechanisms behind differential mRNA decay.
Article Abstract
Differential mRNA stability is an important mechanism for regulation of virulence factors in Streptococcus pyogenes (group A streptococcus, GAS), a serious and prevalent human pathogen. We have described 2 Classes of mRNA in GAS that are distinguishable by 1) stability in the stationary phase of growth, 2) kinetics of decay in exponential phase, and 3) effect of depletion of RNases J1 and J2 and polynucleotide phosphorylase (PNPase) on decay in exponential phase. We discuss features of the structure of an mRNA that appear to be important for determining the Class to which it belongs and present a model to explain differential mRNA decay.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073253 | PMC |
| http://dx.doi.org/10.4161/rna.7.5.13097 | DOI Listing |
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