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The dual Ras-association domains of Drosophila Canoe have differential roles in linking cell junctions to the cytoskeleton during morphogenesis.
J Cell Sci
December 2024
Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Article Synopsis
- Cells must change shape and move during development without disrupting tissue structure, requiring strong connections between adherens junctions and the actomyosin cytoskeleton.
- Drosophila Canoe and mammalian Afadin are critical for this process, and understanding how Ras-family GTPases influence their function is a major focus of research.
- Through experiments, researchers found that although both RA1 and RA2 domains bind to active Rap1 with similar strengths, they have different roles in Canoe function, with RA1 being essential while RA2 contributes to junction stability in certain developmental stages.
The Dilute domain in Canoe is not essential for linking cell junctions to the cytoskeleton but supports morphogenesis robustness.
J Cell Sci
March 2024
Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
Article Synopsis
- The study focuses on the protein Canoe and its role in maintaining strong connections between adherens junctions and the actomyosin cytoskeleton, which is essential for cell shape changes during morphogenesis without damaging tissues.
- It investigates the functionality of Canoe's largest domain, the Dilute domain, using various scientific methods, including structural predictions and mutant analysis.
- Findings indicate that while mutants lacking the Dilute domain (CnoΔDIL) can survive and reproduce, they still show defects in eye development, demonstrating the critical role of junction-cytoskeletal connections in cellular movements and the evolutionary preservation of protein structures.
Capture Response and Long-Term Fate of White Sharks () after Release from SMART Drumlines.
Biology (Basel)
October 2023
NSW Department of Primary Industries, Sydney Institute of Marine Science, Mosman, NSW 2088, Australia.
Human-shark conflict has been managed through catch-and-kill policies in most parts of the world. More recently, there has been a greater demand for shark bite mitigation measures to improve protection for water users whilst minimizing harm to non-target and target species, particularly White Sharks (), given their status as a Threatened, Endangered, or Protected (TEP) species. A new non-lethal shark bite mitigation method, known as the Shark-Management-Alert-in-Real-Time (SMART) drumline, alerts responders when an animal takes the bait and thereby provides an opportunity for rapid response to the catch and potentially to relocate, tag, and release sharks.
View Article and Find Full Text PDFExploring the evolution and function of Canoe's intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis.
PLoS One
August 2023
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.
One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway.
View Article and Find Full Text PDFExploring the evolution and function of Canoe’s intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis.
bioRxiv
March 2023
Department of Biology, University of North Carolina at Chapel Hill, CB#3280, Chapel Hill, NC 27599-3280, USA.
One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway.
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