Aim: To study the relationship between serum inflammation factors interleukin-8 (IL-8), high-sensitivity C-reaction protein, tumor necrosis factor-α and coronary lesions in coronary heart disease (CHD) patients,
Methods: One hundred and six CHD patients were enrolled, 100 healthy subjects served as control group. The levels of serum IL-8, hsCRP (by) and TNF-α were determined. Coronary lesions were calculated by Gensini method.
Results: The levels of Serum IL-8, hsCRP and TNF-α in CHD group were significantly higher than those in control group were significantly higher than those in control group (P < 0.05), and serum IL-8, hsCRP and TNF-α in CHD group increased gradually with the increase of Gensini score (P < 0.05). Pearson correlation analysis showed that Gensini score was positively correlated to IL-8 (P < 0.05), hsCRP (P < 0.05) and TNF-α (P < 0.05) in CHD group.
Conclusion: Severity of coronary lesions in CHD patients may be related to the levels of serum IL-8, hsCRP and TNF-α.
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