AI Article Synopsis
- The study investigates how coumestrol affects calcium metabolism in pregnant and lactating mice.
- Pregnant mice given coumestrol showed decreased alkaline phosphatase activity and changes in gene expressions related to calcium absorption in their intestines.
- In lactating mice, while some gene expressions were still affected by coumestrol, alkaline phosphatase activity remained unchanged, indicating different effects during and after pregnancy.
Article Abstract
The present study was conducted to clarify the effects of coumestrol administration on Ca metabolism during pregnancy and in lactating mice. From 6.5 to 16.5 days post coitus (dpc), pregnant mice were administered coumestrol at 200 µg/kg body weight/day. The duodenum, jejunum and blood samples were obtained at 17.5 dpc or 10 days after parturition (dap). Coumestrol administration decreased alkaline phosphatase (ALP) activity and mRNA expression of IAP and estrogen responsive genes, c-fos and vascular endothelial growth factor (VEGF), in the duodenum and jejunum of pre-delivery mice. In lactating mice, the ALP activity and mRNA expression of IAP were not changed, although coumestrol administration decreased mRNA expression of c-fos in the duodeum and VEGF in the jejunum. Coumestrol did not affect serum Ca and the expression of vitamin D receptor protein in the duodenum and jejunum. Thus, coumestrol administration during pregnancy may decrease the mRNA expression of IAP and the ALP activity in the intestine of the pre-delivery mice through ERα, but coumestrol had little effect on intestinal ALP activity at 10 days after parturition.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ptr.3317 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioinformatics-based drug repositioning and prediction of the main active ingredients and potential mechanisms of action for the efficacy of Dan-Lou tablet.
Sci Rep
October 2024
School of Pharmacy, Lanzhou University, Lanzhou, 730000, Gansu, China.
Drug repositioning is gaining attention as a method for developing new drugs due to its low cost, short cycle time, and high success rate. One important approach is to explore new uses for already marketed drugs. In this study, we utilized the strategy of drug repositioning, focusing on the Dan-Lou tablet.
View Article and Find Full Text PDFDiscovering the direct relations between nutrients and epigenetic ageing.
J Nutr Health Aging
September 2024
Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, Netherlands.
Article Synopsis
- As people get older, age-related diseases are becoming more common, which puts pressure on healthcare systems, making it important to support healthy ageing.
- Researchers looked at over 3,900 postmenopausal women to study how certain nutrients affect biological age using a tool called the PhenoAge epigenetic clock.
- They found that eating more good nutrients like coumestrol and beta-carotene can slow down ageing, while too much sugar and certain fats can speed it up.
Coumestrol induces oxidative stress and impairs migration and embryonic growth.
Reproduction
July 2023
Department of Cell Biology and Physiology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
In Brief: Healthy development of the placenta is dependent on trophoblast cell migration and reduced oxidative stress presence. This article describes how a phytoestrogen found in spinach and soy causes impaired placental development during pregnancy.
Abstract: Although vegetarianism has grown in popularity, especially among pregnant women, the effects of phytoestrogens in placentation lack understanding.
Protective Effects of Coumestrol on Metabolic Dysfunction and Its Estrogen Receptor-Mediated Action in Ovariectomized Mice.
Nutrients
February 2023
Department of Food Science and Biotechnology, Andong National University, Andong 36729, Republic of Korea.
Coumestrol, a phytoestrogen compound found in various plants, has been shown to act as a potent estrogen receptor (ER) agonist, with a higher binding affinity for ERβ than for ERα. However, there is currently limited information regarding its beneficial effects in postmenopausal disorders and its ER-mediated mechanisms. Herein, we investigated the effects of coumestrol (subcutaneous or oral treatment) on metabolic dysfunction in ovariectomized (OVX) mice fed a high-fat diet, in comparison with the effects of 17β-estradiol (E2) replacement.
View Article and Find Full Text PDFCoumestrol pre-treatment improves spatial learning and memory deficits following transient cerebral ischemia recruiting hippocampal GluR2 AMPA receptors.
Hippocampus
June 2022
Department of Biochemistry, Institute for Basic Health Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Transient global ischemia is a leading cause of learning and memory dysfunction and induces a pattern of delayed neuronal death in the CA1 subfield of the hippocampus by down-regulating GluR2 mRNA AMPA receptors in this cerebral area. This study sought to investigate the neuroprotective effect of coumestrol against spatial memory impairment induced by global ischemia that leads to neural death by reducing the GluR2 receptors content in the hippocampal CA1 area. Our studies demonstrated that coumestrol administration prevented spatial memory deficits in mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!