Severity: Warning
Message: fopen(/var/lib/php/sessions/ci_sessionc1gcsfg57l5g8cf57qmb6s7250076m69): Failed to open stream: No space left on device
Filename: drivers/Session_files_driver.php
Line Number: 177
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Severity: Warning
Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)
Filename: Session/Session.php
Line Number: 137
Backtrace:
File: /var/www/html/index.php
Line: 316
Function: require_once
Activation of the nuclear factor-κB (NF-κB) family of transcription factors results in the expression of numerous genes involved in the regulation of the innate and adaptive immune responses, and has been implicated as a key mechanism in chronic inflammatory diseases including rheumatoid arthritis (RA). The IκB kinases (IKKs) are key components in the signaling pathway by which proinflammatory stimuli, such as lipopolysaccharide and tumor necrosis factor-α lead to the activation of NF-κB. The most widely studied of the IKKs is IKKβ. Inhibitors of the kinase activity of IKKβ offer opportunities for intervention in RA, as well as other inflammatory disorders. Some examples for which the most extensive data are available will here be reviewed.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1358/dnp.2010.23.8.1447844 | DOI Listing |
J Rheumatol
March 2025
J. Tofferi, MD, Brooke Army Medical Center, Department of Rheumatology.
Objective: To understand the ordering patterns of the antinuclear antibody (ANA) multiplex testing in a single, large Department of Defense (DoD) tertiary healthcare system.
Methods: Records of patients with an ANA multiplex assay ordered over a one-year period were evaluated in a large DoD hospital system. Duplicate tests and patients with a previously established Autoimmune Rheumatic Disease (ARD) prior to the year of study were excluded.
Autoimmun Rev
March 2025
Unitat de Recerca de Lípids i Arteriosclerosi, Universitat Rovira i Virgili, Reus, Institut d'Investigació Sanitària Pere Virgili, Tarragona, Spain.
Objective: To evaluate the efficacy, safety, and tolerability of antifibrotic agents, nintedanib and pirfenidone, in the treatment of rheumatoid arthritis-associated interstitial lung disease (RA-ILD).
Methods: A systematic literature review was conducted following PRISMA and MOOSE guidelines. Studies assessing nintedanib or pirfenidone in RA-ILD were included.
Free Radic Biol Med
March 2025
Center for Drug Research and Development, Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong, China. Electronic address:
Auranofin (AF) is a gold-based compound and it has been used in the treatment of rheumatoid arthritis for over four decades. Recently, it has been demonstrated to show significant antitumor activity across various cancer types and is being repurposed as an anticancer drug. However, the precise mechanisms underlying its antitumor effects, particularly its binding targets, remain poorly understood.
View Article and Find Full Text PDFPharmacol Res
March 2025
State Key Laboratory of Traditional Chinese Medicine Syndrome /The Second Clinical College, Guangzhou University of Chinese Medicine, Guangdong Province 510405, China; State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Taipa, Macao, PR China; Chinese Medicine Guangdong Laboratory (Hengqin Laboratory), Guangdong-Macao In-Depth Cooperation Zone in Hengqin 519000, China. Electronic address:
Bone destruction in rheumatoid arthritis (RA) leads to significant disability, yet effective treatments are limited. Sinomenine (Sino) demonstrates anti-arthritic and bone-protective effects but requires high doses. In this study, we developed a Sino derivative, SINX, and evaluated its efficacy in RA.
View Article and Find Full Text PDFPathol Res Pract
March 2025
Biochemistry Department, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt.
Rheumatoid arthritis (RA) is one of the most common chronic autoimmune diseases. Chronic joint inflammation and bone destruction were shown to be caused by expanded monocytes in RA affected individuals. Interleukin-37 which known as FIL1Z(IL-37) is a well-known anti-inflammatory cytokine that plays a negative regulatory role of inflammation in RA.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!