Background: Post-traumatic seizures cause secondary brain injury, contributing to morbidity and mortality after traumatic brain injury. Seizure activity may be undetectable if the patient is paralysed and ventilated.
Aims: The effect of prophylactic anticonvulsant therapy on the prevention of seizures after moderate to severe traumatic brain injury was studied.
Methods: A structured systematic literature review was performed.
Results: There may be a place for prophylactic anticonvulsants in the prophylaxis of early post-traumatic seizures.
Conclusion: Further randomised controlled trials are needed to firmly establish the benefits of prophylactic anticonvulsants.
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| http://dx.doi.org/10.1007/s12245-010-0180-1 | DOI Listing |
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