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| http://dx.doi.org/10.1136/bjo.2010.195214 | DOI Listing |
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Antifungal susceptibility, clinical findings, and biofilm resistance of Fusarium species causing keratitis: a challenge for disease control.
Braz J Microbiol
January 2025
Federal University of Ceará Fortaleza, Ceará, Brazil.
Fusarium keratitis (FK) is an important clinical condition that can lead to blindness and eye loss, and is most commonly caused by the Fusarium solani species complex (FSSC). This study evaluated the susceptibility of planktonic cells and biofilms of FSSC (n = 7) and non-FSSC (n = 7) isolates obtained from patients with keratitis from a semi-arid tropical region to amphotericin B (AMB), natamycin (NAT), voriconazole (VRZ), efinaconazole (EFZ), and luliconazole (LCZ). Analysis of clinical data showed that trauma was the most common risk factor for FK patients.
View Article and Find Full Text PDF8-Hydroxyquinoline derivative as a promising antifungal agent to combat ocular fungal infections.
J Med Microbiol
January 2025
Programa de Ps-Graduao em Cincias Farmacuticas, Faculdade de Farmcia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Ocular fungal infections are pathologies of slow progression, occurring mainly in the cornea, but can also affect the entire structure of the eyeball. The main aetiological agents are species of the genera and . Both diagnosis and treatment require speed and effectiveness.
View Article and Find Full Text PDFEvaluation of topical 1% posaconazole therapy in refractory fungal keratitis.
Indian J Ophthalmol
January 2025
Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India.
Purpose: The primary objective was to evaluate the clinical response of refractory cases of fungal keratitis to topical 1% posaconazole therapy.
Methods: Prospective longitudinal non-randomized open label dual-cohort study of 70 eyes of refractory fungal keratitis, 35 were recruited as posaconazole treatment (PCZ) group for topical 1% posaconazole therapy and compared to 35 eyes on conventional antifungal therapy. Study parameters included demographic and treatment details, visual acuity, comprehensive slit-lamp biomicroscopy, clinical photography, ASOCT at recruitment and weekly (week 1, 2, 3 and 4 after treatment initiation).
Antifungal resistance, clinical outcome and clinico-microbiological correlation in ocular infections due to common melanized fungi and in South India.
J Med Microbiol
November 2024
Jhaveri Microbiology Centre, Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, 500034, India.
Melanized fungi were rarely studied for their antifungal resistance (AFR) or clinical outcome, despite rising incidence of melanized fungal ocular infections and AFR in general. We report the antifungal resistance patterns, clinical outcome and clinico-microbiological correlation in two commonly isolated melanized fungi from ocular infections, and , at a tertiary eyecare centre in South India..
View Article and Find Full Text PDFAssessing the Efficacy of Chlorhexidine in Combating Most Important Causative Agents of Fungal Keratitis: An Comparative Study With Seven Antifungal Agents.
Curr Eye Res
October 2024
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study focused on comparing the effectiveness of chlorhexidine (CHX) and seven antifungal agents against fungi from patients with fungal keratitis (FK).
- Testing involved 73 fungi samples using a standard method, where CHX demonstrated notable efficacy against various types of fungi at specific concentrations.
- Results suggested that CHX could be a cost-effective topical treatment for FK, especially in areas with limited access to antifungal medications, while posaconazole was identified as the most effective antifungal overall.
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