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Otocephaly Diagnosed Prenatally: A Case Study of a Rare Congenital Defect.
Birth Defects Res
December 2024
Department of Obstetrics and Gynecology, Perinatology unıt of Elazığ City Hospital, Elazığ, Turkey.
Background: Agnathia-otocephaly complex (AOC) is a rare and complex craniofacial malformation characterized by mandibular hypoplasia or agnathia, auricular fusion, microstomia with oroglossal hypoplasia or aglossia. It has a very bad prognosis and can arise alone or in conjunction with heart defects and forebrain abnormalities.
Case Report: A standard second-trimester ultrasound exam was recommended for, a 23-year-old primigravida woman who was at 22 weeks gestation.
Vanishing Bile Duct Syndrome in Pediatric Hodgkin Lymphoma: First Statistical Analysis of All Published Cases in Children and a Case Report.
J Pediatr Hematol Oncol
January 2025
Departments of Pediatric Hematology/Oncology and Bone Marrow Transplant.
Hodgkin lymphoma with vanishing bile duct syndrome is a rare paraneoplastic syndrome and has never been studied in the pediatric population. The objectives of this study were to determine the clinical characteristics of this rare condition in children through a literature review, and a descriptive analysis of all published cases with the index case report. All reported cases fulfilling the inclusion criteria were found through a literature search, and analyzed in descriptive statistics.
View Article and Find Full Text PDFCigarette Smoke Exposure Impairs Fracture Healing in a Rat Model: Preferential Impairment of Endochondral Over Membranous Healing.
J Biomech Eng
January 2025
Department of Orthopaedics and Physical Medicine, Medical University of South Carolina, Bioengineering Building 227, 68 President Street, Charleston, SC 29425; Department of Orthopaedics, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, 1 Medical Center Drive, Lebanon, NH 03756.
Article Synopsis
- Cigarette smoking negatively impacts the healing process of fractures, specifically delaying healing and increasing the risk of nonunion.
- The study tested how cigarette smoke affects two types of bone healing (intramembranous vs. endochondral) using rat models with femur fractures treated with different methods.
- Results showed that fractures treated with compression plating healed faster and more completely than those treated with intramedullary nailing, particularly in smoke-exposed animals, suggesting better surgical outcomes for smokers if compression plating is used.*
Insulin-Like Growth Factor-Binding Protein 5 Promotes the Cell Proliferation and Osteogenic Potential of Dental Pulp Stem Cells Dependent on Its Nuclear Localisation Sequence.
J Oral Rehabil
December 2024
Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.
Objectives: Dental pulp stem cells (DPSCs) have been extensively used for tissue regeneration owing to their notable capabilities. Insulin-like growth factor-binding protein 5 (IGFBP5) regulates osteogenic differentiation of mesenchymal stem cells (MSCs); however, the underlying regulatory mechanisms require further investigation.
Materials And Methods: Carboxyfluorescein succinimidyl ester, an alkaline phosphatase (ALP) activity assay and Alizarin Red staining were used to reveal the role of IGFBP5 in DPSCs.
An attention-based deep learning for acute lymphoblastic leukemia classification.
Sci Rep
July 2024
Faculty of Engineering and Information Technology, University of Technology Sydney, Sydney, NSW, 2007, Australia.
The bone marrow overproduces immature cells in the malignancy known as Acute Lymphoblastic Leukemia (ALL). In the United States, about 6500 occurrences of ALL are diagnosed each year in both children and adults, comprising nearly 25% of pediatric cancer cases. Recently, many computer-assisted diagnosis (CAD) systems have been proposed to aid hematologists in reducing workload, providing correct results, and managing enormous volumes of data.
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