AI Article Synopsis
- The study explored the effects of a gluten-free diet on health and well-being in symptomatic and asymptomatic patients with celiac disease, highlighting the importance of serologic screening.
- A total of 698 adults were analyzed, with results showing that self-perceived health significantly improved in those with classic symptoms on a gluten-free diet, while anxiety related to health decreased across all groups.
- In contrast, the 23 asymptomatic patients showed a decline in their health perception and increased health concerns while on the gluten-free diet, raising questions about the benefits of screening asymptomatic individuals.
Article Abstract
Background & Aims: The benefits of serologic screening and early diagnosis of celiac disease in asymptomatic patients are not known. We investigated the impact of a gluten-free diet on self-perceived health and well-being in symptomatic and asymptomatic patients with celiac disease.
Methods: We performed a prospective study of 698 consecutive adults newly diagnosed with celiac disease because of classic (n = 490) or extraintestinal (n = 62) symptoms or through screening of at-risk groups (n = 146; 23 were asymptomatic and analyzed separately). The survey included questions on health and well-being; quality of life was evaluated by the psychological general well-being (PGWB) questionnaire. Patients were followed for 1 year of treatment; 110 healthy subjects served as controls.
Results: On a gluten-free diet, self-perceived health improved significantly among patients with classic symptoms and those detected by screening. Patients in all groups were equally concerned about their health before the diagnosis, but anxiety was alleviated by the gluten-free diet. At diagnosis, the quality of life reduced among all 3 groups but improved significantly among patients on the diet. Among the 23 asymptomatic patients, perception of health worsened and concern about health increased while they were on the diet.
Conclusions: Self-perceived health and well-being were low among patients at the time they were diagnosed with celiac disease. Most patients benefited from a gluten-free diet, so it is important to identify patients with celiac disease. Perception of health decreased among asymptomatic cases, which discourages population-based screening.
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| http://dx.doi.org/10.1016/j.cgh.2010.10.011 | DOI Listing |
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