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GCY-20 signaling controls suppression of Caenorhabditis elegans egg laying by moderate cold.
Cell Rep
February 2024
Key Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Organisms sensing environmental cues and internal states and integrating the sensory information to control fecundity are essential for survival and proliferation. The present study finds that a moderate cold temperature of 11°C reduces egg laying in Caenorhabditis elegans. ASEL and AWC neurons sense the cold via GCY-20 signaling and act antagonistically on egg laying through the ASEL and AWC/AIA/HSN circuits.
View Article and Find Full Text PDFFocal acetylcholinergic modulation of the human midcingulo-insular network during attention: Meta-analytic neuroimaging and behavioral evidence.
J Neurochem
April 2024
Robarts Research Institute, Western University, London, Ontario, Canada.
The basal forebrain cholinergic neurons provide acetylcholine to the cortex via large projections. Recent molecular imaging work in humans indicates that the cortical cholinergic innervation is not uniformly distributed, but rather may disproportionately innervate cortical areas relevant to supervisory attention. In this study, we therefore reexamined the spatial relationship between acetylcholinergic modulation and attention in the human cortex using meta-analytic strategies targeting both pharmacological and non-pharmacological neuroimaging studies.
View Article and Find Full Text PDF[Molecular and clinical aspects of the effect of cytidyndiphosphocholine on cognitive functions].
Zh Nevrol Psikhiatr Im S S Korsakova
June 2021
Ivanovo State Medical Academy of the Ministry of Health of Russia, Ivanovo, Russia.
Objective: Systematization of the array of publications on cytidyldiphosphocholine (CDP-choline).
Material And Methods: Systematic computer analysis of all currently available publications on CDP-choline (1750 publications in PUBMED) using the topological theory of big data analysis.
Results: CDP-choline is essential for acetylcholine biosynthesis, phospholipid metabolism, and DNA methylation.
Differential Impact on Isolated REM Sleep without Atonia by Varying Antidepressant Therapies.
J Affect Disord Rep
December 2020
Mayo Center for Sleep Medicine, Mayo Clinic, Rochester, Minnesota.
Background: REM sleep without atonia (RSWA) is characterized by increased phasic or tonic muscle activity in electromyography channels during polysomnography and usually causes REM sleep behaviour disorder, but RSWA also exists within healthy populations without dream-enactment behaviour, especially in psychiatric populations receiving antidepressant therapies. Evidence for differential impact of antidepressants on RSWA, and whether RSWA persists or resolves following changes in antidepressant therapy, remains limited.
Case: We present a 56-year-old woman with depression undergoing 3 polysomnograms while receiving 3 different distinct antidepressants.
Mechanisms of Non-coenzyme Action of Thiamine: Protein Targets and Medical Significance.
Biochemistry (Mosc)
August 2019
Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, 119991, Russia.
Thiamine (vitamin B1) is a precursor of the well-known coenzyme of central metabolic pathways thiamine diphosphate (ThDP). Highly intense glucose oxidation in the brain requires ThDP-dependent enzymes, which determines the critical significance of thiamine for neuronal functions. However, thiamine can also act through the non-coenzyme mechanisms.
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