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Alzheimers Dement
December 2024
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Background: Mild Cognitive Impairment (MCI) is often a precursor to Alzheimer's dementia (AD). Recent research underscores the relationship between mitochondrial dysfunction and amyloid-beta accumulation, raising the prospect of targeting mitochondrial function for intervention. Transcranial photobiomodulation (tPBM), a non-invasive technique utilizing near-infrared light, has been shown to enhance mitochondrial function.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.
Background: Mild Cognitive Impairment (MCI) serves as a precursor to Alzheimer's dementia (AD). Recent research underscores the relationship between mitochondrial dysfunction and amyloid beta accumulation, underscoring the prospect of targeting mitochondrial function for intervention. Consequently, our study aimed to explore the efficacy of transcranial photobiomodulation (tPBM), a novel non-invasive technique utilizing near-infrared light to activate mitochondrial cytochrome C oxidase receptors, thereby enhancing cellular energy in individuals with MCI.
View Article and Find Full Text PDFThe Yeast F-Box Protein Met30 Regulates Proline Utilization Independently of Transceptor Can1 Under Nutrient-Rich Conditions.
Microorganisms
December 2024
Institute for Research Initiatives, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma 630-0192, Nara, Japan.
Proline is the most abundant amino acid in wine and beer, largely due to the limited utilization of proline by the yeast during fermentation. Previous studies have shown that the arginine transporter Can1 plays a role in regulating proline utilization by acting as a transceptor, combining the functions of both a transporter and a receptor for basic amino acids. However, the -disrupted strains have exhibited the inhibition of proline utilization under nutrient-rich conditions, indicating that additional factors beyond basic amino acids contribute to the inhibition of proline utilization.
View Article and Find Full Text PDFIntracorneal iontophoretic delivery of triamcinolone acetonide prodrugs: Physicochemical parameters guiding electrotransport.
Int J Pharm
December 2024
School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland; Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Geneva, Switzerland. Electronic address:
Intracorneal delivery of ten amino acid (alanine, arginine, asparagine, glutamine, glycine, histidine, isoleucine, lysine, methionine and valine) ester prodrugs of triamcinolone acetonide (TA-AA) was investigated in vitro, using a corneal iontophoresis device (IONTOFOR-CXL; SOOFT Italia S.p.A.
View Article and Find Full Text PDFNutrients and Quality Aspects Characterizing Cultivated in Valli di Comacchio (Northern Italy) Across Different Seasons.
Molecules
November 2024
Department of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari 46, 44121 Ferrara, Italy.
The quality aspects of () cultured in Valli di Comacchio were examined across different seasons. Nutritional quality parameters, antioxidant activity, total carotenoids, and contaminants were determined in winter, summer, and autumn (December, June, and October). Seasonal variations in nutritional parameters were observed.
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