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Role of detrusor overactivity and interval between bladder sensations on the severity of overactive bladder symptoms in patients with multiple sclerosis.
Fr J Urol
December 2024
GRC 01, GREEN Group of clinical REsEarch in Neurourology, Sorbonne University, Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
Purpose: This study aimed to assess the relationship between kinetics of bladder sensations perception, detrusor overactivity (DO), and severity of overactive bladder (OAB) symptoms in patients with multiple sclerosis (PwMS).
Methods: All PwMS who underwent urodynamic assessment including three cystometries (20mL/min, 100mL/min, and 100mL/min with 4°C fluid) between June 2020 and October 2022 were included in this retrospective study. Data collected were bladder diaries, symptoms assessed with Urinary Symptom Profile (USP), bladder sensations with first desire to void (FDV) and strong desire to void (SDV) during the 20mL/min cystometry, and presence of DO.
Lower Urinary Tract Dysfunction Among Patients Undergoing Surgery for Deep Infiltrating Endometriosis: A Prospective Cohort Study.
J Clin Med
December 2024
Department of Obstetrics and Gynecology, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.
: Postsurgical lower urinary tract dysfunction (LUTD) is a common problem following deep infiltrating endometriosis (DIE) resection. The condition may be caused either by surgically induced damage to the bladder innervation or by pre-existing endometriosis-associated nerve damage. The aim of this study is to evaluate the efficacy of preoperative and postoperative multichannel urodynamic testing (UD) in identifying pre-existing or surgically induced LUTD among patients with DIE.
View Article and Find Full Text PDFRecoverability of Bladder Function in Patients With Defunctionalized Bladder and Live-Donor Kidney Transplantation.
Transplant Proc
December 2024
Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.
Background: The purpose of this article was to assess the recoverability of bladder, in a subset of patients with uremia, planned for live-donor kidney transplantation.
Methods: Patients referred to the Voiding Dysfunction Unit for evaluation, prior to transplantation, were included in this study during the period 2004 to 2008 in a single institution with a track record in live-donor transplantation. Defunctionalized bladder was defined as patients with complete anuria or oliguria for at least 6 months.
Genetic tools that target mechanoreceptors produce reliable labeling of bladder afferents and altered mechanosensation.
Am J Physiol Renal Physiol
November 2024
Department of Pathobiological Sciences, University of Wisconsin-Madison School of Veterinary Medicine, Madison, WI, USA.
Article Synopsis
- Mechanosensitive neurons play a crucial role in sensing bladder stretching, but their involvement in urologic diseases is not well understood, especially regarding CGRP-negative mechanoreceptors.
- A study found a significant number of bladder nerve fibers that are NFH-positive but CGRP-negative, indicating potential unexplored mechanoreceptors.
- By using genetic strategies to label these mechanoreceptors, researchers demonstrated that TrkB neurons are essential for bladder mechanosensation, as the absence of these neurons increased the pressure required for voiding and led to non-voiding contractions after bladder distention.
An evidence-based approach to the recovery of bladder and bowel function after pediatric spinal cord injury.
J Clin Neurosci
October 2023
Department of Neurological Surgery, University of Louisville, Louisville, KY, United States; Kentucky Spinal Cord Injury Research Center, University of Louisville, Louisville, KY, United States; School of Medicine, University of Louisville, Louisville, KY, United States.
Introduction: Bladder dysfunction and associated complications of the urinary system negatively impact the quality of life in children living with spinal cord injury (SCI). Pediatric lower urinary tract deficits include bladder over-activity, inefficient emptying, decreased compliance, and incontinence. Recent evidence in adults with SCI indicates significant improvements in bladder capacity and detrusor pressure following participation in an activity-based recovery locomotor training (ABR-LT) rehabilitative program.
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