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The Development of Opioid Vaccines as A Novel Strategy for the Treatment of Opioid Use Disorder and Overdose Prevention.
Int J Neuropsychopharmacol
January 2025
Department of Psychiatry and Psychology, Mayo Clinic; Rochester, Minnesota, USA.
Opioid use disorder (OUD) affects over 40 million people worldwide, creating significant social and economic burdens. Medication for opioid use disorder (MOUD) is often considered the primary treatment approach for OUD. MOUD, including methadone, buprenorphine, and naltrexone is effective for some, but its benefits may be limited by poor adherence to treatment recommendations.
View Article and Find Full Text PDFContribution of crossing over to genetic variance in maize and wheat populations.
Plant Genome
March 2025
Department of Agronomy and Plant Genetics, University of Minnesota, Saint Paul, Minnesota, USA.
Crossing over breaks linkages and leads to a wider array of allele combinations. My objective was to assess the contribution of crossing over to genetic variance (V) in maize (Zea mays L.) and wheat (Triticum aestivum L.
View Article and Find Full Text PDFUnderstanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.
Hum Brain Mapp
December 2024
Department of Psychology, Northeastern University, Boston, Massachusetts, USA.
Diffusion-weighted imaging (DWI) has been frequently used to examine age-related deterioration of white matter microstructure and its relationship to cognitive decline. However, typical tensor-based analytical approaches are often difficult to interpret due to the challenge of decomposing and (mis)interpreting the impact of crossing fibers within a voxel. We hypothesized that a novel analytical approach capable of resolving fiber-specific changes within each voxel (i.
View Article and Find Full Text PDFIn an environment increasingly dominated by roads, wildlife crossing structures (WCS) have been installed to decrease wildlife mortality and improve habitat linkages. In South Texas, vehicle collisions have been a major mortality source for the endangered ocelot (). To mitigate threats to this species, eight WCS, along with associated fencing, were strategically placed along Farm-to-Market Road 106 (FM106), which passes through ocelot habitat.
View Article and Find Full Text PDFDesigning novel Au(III) complexes based on the structure of diazepam: Achieving a multiaction mechanism against glioma.
Eur J Med Chem
February 2025
Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation, Guangxi Health Commission Key Laboratory of Tumor Immunology and Receptor-Targeted Drug Basic Research, Guilin Medical University, Huan Cheng North 2nd Road 109, Guilin, 541004, PR China. Electronic address:
Metal-based drugs have been used in the clinical treatment of tumors for over 30 years. However, no metal-based drugs have been clinically approved to treat glioma. Although metal complexes have excellent cytotoxicity, their most critical problem is crossing the blood-brain barrier.
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