Hb Davenport is a new, stable alpha chain variant, that was detected in two members of a Caucasian family living in Iowa. Hematological data were within normal limits. It is characterized by an Asn----His replacement at position alpha 78. Mild acidic hydrolysis of the large alpha T-9 peptide, separation of the resulting fragments by reversed phase high performance liquid chromatography, and sequence analysis of a few of these peptides greatly facilitated the identification of this substitution.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3109/03630269009046968 | DOI Listing |
Publication Analysis
Top Keywords
davenport alpha
4
alpha 278ef7asn----his
4
278ef7asn----his beta
4
beta davenport
4
davenport stable
4
stable alpha
4
alpha chain
4
chain variant
4
variant detected
4
detected members
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!