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Unraveling the Therapeutic Potential of Sophora flavescens Aiton in Myocardial Infarction: An Integrative Approach Combining Bioinformatics, Network Pharmacology, and Experimental Validation.
Curr Pharm Des
January 2025
Second Affiliated Hospital, Naval Medical University, Shanghai 200433, China.
Aims: This study aims to elucidate the relationship between potential MI targets and SFA's mechanism of action, providing a theoretical basis for clinical development of new drugs.
Background: Myocardial infarction (MI) has been identified as one of the major cardiovascular diseases with adverse consequences. Sophora flavescens Aiton (SFA) is indicated for the therapeutic treatment of MI.
Flavonoids and Kavalactones Isolated from Seeds of Alpinia katsumadai Hayata. and Their Cytotoxic Activities.
Chem Biodivers
January 2025
Guizhou Medical University, School of Pharmaceutical Sciences, University Town, Gui'an New District, 550025, Guiyang, CHINA.
An unrevealed dihydroflavone-monoterpene conjugate (1), two unrevealed kavalactones (2-3, including one with an uncommon side chain), and thirteen previously identified compounds (4-16) were extracted from Alpinia katsumadai Hayata. seeds. The two-dimension structures of the new compounds were authenticated utilizing HRESIMS as well as NMR spectral analysis, while their absolute chiral configurations were ascertained either by correlating the experimental and simulated values of electronic circular dichroism (ECD) patterns or conducting X-ray diffraction experiments.
View Article and Find Full Text PDFSirt1 Regulates Phenotypic Transformation of Diabetic Cardiac Fibroblasts through Akt/Α-SMA Pathway.
Curr Mol Pharmacol
January 2025
Department of Cardiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212000, Jiangsu, China.
Aims: Cardiac fibrosis causes most pathological alterations of cardiomyopathy in diabetes and heart failure patients. The activation and transformation of cardiac fibroblasts (CFs) are the main pathological mechanisms of cardiac fibrosis. It has been established that Sirtuin1 (Sirt1) plays a protective role in the pathogenesis of cardiovascular disorders.
View Article and Find Full Text PDFEffect of dietary microalgae on growth performance and health in meat-type quails.
Poult Sci
December 2024
Department of Veterinary Medicine, University of Bari Aldo Moro, S.P. per Casamassima km 3, Valenzano, BA 70010, Italy.
The purpose of this work was to ascertain the impact of dietary inclusion of Dunaliella salina (Ds) and Arthrospira platensis (Ap) mixture as growth promoters on growth performance, carcass traits, liver and renal function, lipid profile, immunology and economics in quail chicks. 240 Un -sexed seven-day quail chicks were separated into four treatment groups with six replicates of ten chicks per group. The treatment groups are: control: basal diet; DsAp0.
View Article and Find Full Text PDFTowards Rational Design of Confined Catalysis in Carbon Nanotube by Machine Learning and Grand Canonical Monte Carlo Simulations.
Angew Chem Int Ed Engl
December 2024
State Key Laboratory of Catalysis, Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, P. R. China.
The microenvironment is recognized to be as crucial as active sites in heterogeneous catalysis. It was found that the catalytic activity of a set of chemical reactions can be significantly influenced by the confined space of carbon nanotubes (CNTs), with some reactions showing superior activity, while others experience a negative impact. The rational design of confined catalysis must rely on the accurate insights of confined microenvironment.
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