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Protective effect of CK2 against endoplasmic reticulum stress in pancreatic β cells.
Diabetol Int
January 2025
Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, 650-0017 Japan.
Unlabelled: Endoplasmic reticulum (ER) stress due to obesity or systemic insulin resistance is an important pathogenic factor that could lead to pancreatic β-cell failure. We have previously reported that CCAAT/enhancer-binding protein β (C/EBPβ) is highly induced by ER stress in pancreatic β cells. Moreover, its accumulation hampers the response of these cells to ER stress by inhibiting the induction of the molecular chaperone 78 kDa glucose-regulated protein (GRP78).
View Article and Find Full Text PDFEffects of laparoscopic sleeve gastrectomy on weight loss and metabolic improvement in subjects aged 65 years or older: a subanalysis of J-SMART study.
Diabetol Int
January 2025
Center of Diabetes, Endocrinology and Metabolism, Toho University Sakura Medical Center, Sakura, Chiba Japan.
Aim: To investigate the effect of weight loss and metabolic improvement after laparoscopic sleeve gastrectomy (LSG) in older adults aged 65 years or over compared with younger adults in a retrospective analysis.
Methods: The J-SMART study database of 322 Japanese individuals with body mass index (BMI) ≥32 kg/m who underwent LSG between 2011 and 2014 at 10 centers accredited by the Japanese Society for Treatment of Obesity were analyzed. The subjects were classified into two groups: ≥65 age group (range, 65-76 years; n = 25) and <65 age group (range, 22-64 years; n = 297).
Glycemic variability and quality of life outcomes after changing to hybrid closed-loop system in Japanese individuals with type 1 diabetes using a conventional predictive low-glucose suspended insulin pump system.
Diabetol Int
January 2025
Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Toho University Graduate School of Medicine, 6-11-1 Omori-Nishi, Ota-ku, Tokyo 143-8541 Japan.
Unlabelled: The hybrid closed-loop (HCL) system, Medtronic MiniMed 770G, has been available for use by Japanese individuals with type 1 diabetes mellitus since 2021. The aim of this study was to evaluate the effect of its use on glycemic variability and quality of life (QOL) in this population. This multicenter, open-label, prospective observational study included 14 Japanese individuals with type 1 diabetes mellitus treated with MiniMed 640G.
View Article and Find Full Text PDFDapagliflozin treatment decreases visceral and subcutaneous adipose tissue: a systematic review and meta-analysis.
Diabetol Int
January 2025
Facultad de Medicina, Benemérita Universidad Autónoma de Puebla, 13 Sur 2901 Colonia Volcanes, 72420 Puebla, Puebla México.
Aims: Sodium-glucose co-transporter-2 inhibitors (SGLT2i) have been shown to reduce visceral (VAT) and subcutaneous (SAT) adipose tissue. Although many systematic reviews have examined SGLT2i's effect on VAT and SAT, a focus analysis of dapagliflozin, one of the more commonly prescribe SGLT2i, has yet to been done. This study aims to determine the effect of dapagliflozin on reducing VAT and SAT in patients with chronic disease.
View Article and Find Full Text PDFExperimental study on the influencing factors and pore production law of CO huff-and-puff in tight sandstone reservoirs.
Sci Rep
January 2025
School of Petroleum Engineering, Xi 'an Shiyou University, Xi'an, Shaanxi, China.
In order to determine the influence of different factors on the CO huff-and-puff displacement effect, a CO huff-and-puff experiment was carried out with Chang 6 tight sandstone samples in Ordos Basin as the research object. Combined with nuclear magnetic resonance technology, the influences of injection pressure, cycle numbers and soaking time on the CO huff-and-puff effect were evaluated, and the optimal CO huff-and-puff parameters were optimized. The microscopic degree of crude oil production in different scale pores was quantitatively characterized.
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