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Novel dog hepatic cytochrome P450 3A293 oxidizes endogenous testosterone and estradiol.
Biochem Pharmacol
March 2025
Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan. Electronic address:
Essential drug-metabolizing enzymes, such as the cytochromes P450 (P450s or CYPs), have been analyzed in dogs, which are frequently used during drug development. Dog CYP3A12, CYP3A26, CYP3A98, and CYP3A99 have been previously identified and analyzed, and in this study, novel dog CYP3A293 cDNA was isolated. CYP3A293 cDNA contains an open reading frame of 503 amino acids and shares 71-77 % and 86-96 % amino acid identity with human and dog CYP3As, respectively.
View Article and Find Full Text PDFThree types of 17β-hydroxysteroid dehydrogenases involved in Japanese eel ovarian steroidogenesis.
Gen Comp Endocrinol
February 2025
Fisheries Technology Institute, Minamiizu Field Station, Japan Fisheries Research and Education Agency, Minamiizu, Kamo, Shizuoka 415-0156, Japan. Electronic address:
The synthesis of estradiol-17β (E2), an important steroid hormone in piscine gametogenesis, is catalyzed by various steroidogenic enzymes under the control of pituitary gonadotropins (Gths), follicle-stimulating hormone (Fsh), and luteinizing hormone (Lh). Among these enzymes, 17β-hydroxysteroid dehydrogenases (Hsd17bs) with 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase activities are crucial enzymes in the synthesis of sex steroid hormones in gonadal and extra-gonadal tissues. In teleost species, although Hsd17b1 is recognized as essential for E2 synthesis, other Hsd17b types have recently been shown to have the potential to produce E2; however, information is limited.
View Article and Find Full Text PDFCharacterizing A21: Natural Cyanobacteria-Based Consortium with Potential for Steroid Bioremediation in Wastewater Treatment.
Int J Mol Sci
December 2024
Department of Biochemistry and Molecular Biology, Universidad Complutense de Madrid, c/Jose Antonio Novais 12, 28040 Madrid, Spain.
Microalga-bacteria consortia are increasingly recognized for their effectiveness in wastewater treatment, leveraging the metabolic synergy between microalgae and bacteria to enhance nutrient removal and overall treatment efficiency. These systems offer a sustainable approach to addressing pollutants such as nitrogen and phosphorus. However, their potential in removing specific contaminants like steroid hormones is less explored.
View Article and Find Full Text PDFDevelopment and Application of a Robust Imine-Based Covalent Organic Framework for Stir Bar Sorptive Extraction of Estrogens in Environmental Water.
Molecules
December 2024
School of Chemistry and Environmental Engineering, Hubei Minzu University, Enshi 445000, China.
A covalent organic framework (COF) based on imine was synthesized using 2,5-dihexoxyterephthalaldehyde (DHT) and 1,3,5-tris(4-aminophenyl) benzene (TAPB) as starting materials. The TAPB-DHT-COF exhibited satisfactory chemical stability, making it a promising adsorbing material for stir bar sorptive extraction (SBSE) of four estrogens, including estrone (E1), β-estradiol (E2), hexestrol (HES), and mestranol (MeEE2), in ambient water samples. The extracted analytes were subsequently analyzed using a high-performance liquid chromatography-diode array detector (HPLC-DAD).
View Article and Find Full Text PDFGene expression profiles of Chinese medaka (Oryzias sinensis) primary hepatocytes in response to estrone (E), 17β-estradiol (E) and estriol (E).
J Environ Sci (China)
June 2025
College of Urban and Environmental Sciences, MOE Laboratory for Earth Surface Process, Peking University, Beijing 100871, China. Electronic address:
The natural estrogens, including estrone (E), 17β-estradiol (E), and estriol (E), are frequently detected in aquatic environment at relatively high levels. The most commonly used biomarkers for estrogens are mainly expressed in the liver of fish. Analyses of the global gene profiling in fish liver cells under estrogens treatment will provide precise toxicogenomic information of the natural estrogens which is still not well known.
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