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Comparative analysis of the physiological and transport functions of various sources of renal proximal tubule cells under static and fluidic conditions in PhysioMimix T12 platform.
Drug Metab Dispos
January 2025
Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas. Electronic address:
In vitro models that can faithfully replicate critical aspects of kidney tubule function such as directional drug transport are in high demand in pharmacology and toxicology. Accordingly, development and validation of new models is underway. The objective of this study was to characterize physiologic and transport functions of various sources of human renal proximal tubule epithelial cells (RPTECs).
View Article and Find Full Text PDFDan-Shen-Yin against ethanol-induced chronic gastric mucosal injury in rats by inhibiting apoptosis via IP3R-controlled calcium release.
J Ethnopharmacol
January 2025
National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District, Tianjin 301617, P. R. China; Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China. Electronic address:
Ethnopharmacological Relevance: The pathogenesis of alcoholic gastric injury has long been a significant topic in the medical field. Dan-Shen-Yin (DSY), a classic traditional Chinese medicine formula, has been shown to alleviate gastric mucosal injury and to treat stomachaches in clinical settings. However, the mechanism by which DSY against alcoholic gastric injury requires further investigation.
View Article and Find Full Text PDFMuscle imaging in facioscapulohumeral muscular dystrophy research: A scoping review and expert recommendations.
Neuromuscul Disord
January 2025
Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
Clinical trial readiness is an important topic in the field of facioscapulohumeral muscular dystrophy (FSHD). As FSHD is a slowly progressive and clinically heterogeneous disease, imaging biomarkers have been proposed to complement clinical outcome measures. Muscle magnetic resonance imaging (MRI), ultrasound and dual energy X-ray absorptiometry (DEXA) have been used to measure disease severity, activity and progression.
View Article and Find Full Text PDFLandscape of Global Pediatric Oncology Publications: A Cross-Sectional Analysis.
JCO Glob Oncol
January 2025
Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN.
Purpose: The academic field of global pediatric oncology is expanding as cancer becomes increasingly recognized as a global health priority for children and adolescents. Here, we aimed to explore the representation of authors, the geographic distribution of research, and the research approaches being used in global pediatric oncology.
Methods: Articles published in () and on the topic of global pediatric oncology were analyzed.
Viewing Asilomar from the Global South.
Science
January 2025
Shobita Parthasarathy is a professor of public policy and director of the Science, Technology, and Public Policy program at the Gerald R. Ford School of Public Policy, University of Michigan, Ann Arbor, MI, USA.
To many in the scientific community, the 1975 Asilomar Conference on Recombinant DNA stands as a singular achievement. This experiment in governance seemed to demonstrate that citizens could trust scientists to anticipate their fields' risks and propose sensible ways to regulate themselves. Over the past half-century, similar efforts have been made to govern controversial areas of research, from geoengineering to artificial intelligence.
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