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Limited Diagnostic Value of miRNAs in Early Trauma-Induced Liver Injury: Only miRNA-122 Emerges as a Late-Phase Marker.
Diagnostics (Basel)
January 2025
Department of Trauma Surgery and Orthopedics, University Hospital Frankfurt, Goethe University Frankfurt, 60596 Frankfurt am Main, Germany.
: Liver injury is common after abdominal trauma. However, the established biomarkers of liver injury, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST), lack accuracy. This study investigates whether specific liver-related microRNAs (miRNAs) are released into the circulation in trauma patients with liver injury and whether they can indicate liver damage in the early phase after major trauma.
View Article and Find Full Text PDFA systematic review and meta-analysis on the impact of early vs. delayed pharmacological thromboprophylaxis in patients with traumatic brain injury.
J Clin Neurosci
February 2025
Department of Internal Medicine, Akhtar Saeed Medical College, Lahore, Pakistan.
Article Synopsis
- Traumatic brain injury (TBI) is linked to serious health issues like venous thromboembolism and higher death rates, making early post-traumatic prophylaxis (PTP) important for patient recovery.
- A systematic review analyzed data from 20 studies with over 87,000 patients, revealing that early PTP significantly cuts the risks of VTE, DVT, PE, and overall mortality compared to later administration.
- The results emphasize the effectiveness of early pharmacologic thromboprophylaxis in improving outcomes for TBI patients, although the timing of administration (within 48 hours) is particularly critical for achieving statistical significance.
Combined ultrasound imaging/neurophysiological evaluation for surgical planning in upper limb traumatic nerve injuries with concomitant vascular damage: Two emblematic cases and a review of litterature.
Ann Chir Plast Esthet
December 2024
Plastic and Reconstructive Surgery, Department of Precision Medicine in Medical, Surgical and Critical Care - University of Palermo, Palermo, Italy.
Article Synopsis
- Traumatic injuries of the upper limb often result in both nerve and vascular damage due to the close proximity of major vessels and nerves, and timely diagnosis of complications like pseudoaneurysms is crucial.
- A study reviewed cases of upper limb trauma over two years, utilizing a combined ultrasound imaging and neurophysiological approach to assess nerve injuries, including two specific late-onset vascular complication cases.
- The findings highlight the enhanced diagnostic accuracy achieved when combining electrophysiology with ultrasonography for assessing nerve injuries, suggesting the need for more extensive studies to validate these promising results.
A longitudinal study of healthcare workers' mental health during Western Australia's unique policy response to COVID-19.
BJPsych Open
December 2024
School of Population Health, Curtin University, Australia; Curtin enAble Institute, Perth, Australia; and Centre for Clinical Interventions, North Metropolitan Health Service, Perth, Australia.
Article Synopsis
- - Western Australia effectively managed COVID-19 public health measures, but healthcare staff still faced significant mental health risks, particularly during the pandemic's early years.
- - A study involving 183 healthcare workers found stable rates of post-traumatic stress, depression, and anxiety over time, but those with initially lower symptoms experienced greater increases, while those with higher symptoms saw smaller declines—a phenomenon described as a "catch-up" effect.
- - Key risk factors for psychological symptom changes included workplace stress, sleep problems, and trauma exposure, while supportive workplace and social networks helped protect mental health, indicating a need for improvements in systemic support for healthcare professionals.
Understanding psychological symptoms among Chinese college students during the COVID-19 Omicron pandemic: Findings from a national cross-sectional survey in 2023.
Compr Psychoneuroendocrinol
November 2024
School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Article Synopsis
- The study surveyed 4,254 Chinese students during the Omicron pandemic to evaluate their mental health, focusing on symptoms of depression, anxiety, and PTSD along with their social support networks.
- Key protective factors against mental health issues included regular exercise and strong social support, while risk factors involved excessive alcohol use, comorbidities, Omicron infection, and irregular sleep patterns.
- The findings highlight the heightened vulnerability of students during the pandemic, emphasizing the need for better social support and healthier lifestyle habits to improve their mental well-being.
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