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Multi- and poly-pharmacology of carbonic anhydrase inhibitors.
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Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2.1.
View Article and Find Full Text PDFComparison of antibiotic-resistant Escherichia coli and extra-intestinal pathogenic E. coli from main river basins under different levels of the sewer system development.
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September 2023
Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
Antimicrobial-resistant Escherichia coli in the aquatic environments is considered a strong indicator of sewage or animal waste contamination and antibiotic pollution. Sewer construction and wastewater treatment plant (WWTP) infrastructure may serve as concentrated point sources of contamination of antibiotic-resistant bacteria and antibiotic resistance genes. In this study, we focused on the distribution of antimicrobial-resistant E.
View Article and Find Full Text PDFVery High-Frequency Ultrasonography Signs in Bilateral Acute Choroidal Effusion Associated with Systemic Sulphonamide Medications: 2 Cases.
Case Rep Ophthalmol
February 2022
Unidad de Retina Quirúrgica y Tumores Intraoculares del Adulto (URQTIA), Área Sanitaria de Santiago de Compostela y Barbanza, Complejo Hospitalario Universitario de Santiago de Compostela, Servizo Galego de Saúde (SERGAS), A Coruña, Spain.
Sulphonamides are commonly used in medicine for several purposes; however, they can lead to significant adverse effects, including idiosyncratic reactions and choroidal detachment corresponding to a forward rotation of the iris-lens diaphragm; this could also evolve into acute transient myopia with possible acute angle closure glaucoma. The risk of such reactions to sulphonamides is approximately 3%. In our communication, we have reported on 2 cases involving patients who suffered choroidal detachments after starting sulphonamide treatments and who were diagnosed with the help of ultrasound biomicroscopy.
View Article and Find Full Text PDFSynthesis, antidiabetic, antioxidant and anti-inflammatory activities of novel hydroxytriazenes based on sulpha drugs.
Heliyon
August 2020
Department of Chemistry, Mohanlal Sukhadia University, Udaipur, India.
The present study is aimed to investigate the anti-inflammatory, antioxidant and antidiabetic activities of three series of hydroxytriazenes based on sulfa drugs viz; Sulphathiazole (ST), Sulfisoxazole (SF) and Sulphamethoxazole (SM). Antidiabetic activities of the synthesized hydroxytriazenes were investigated by α-glucosidase and α-amylase inhibition method and IC values were recorded. The compounds presented significant α-glucosidase and α-amylase inhibition effect with IC values ranging from 122 to 341 μg/mL.
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