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Background: Periportal fibrosis is a severe morbidity caused by both current and past exposure to intestinal schistosomes. We aimed to assess the association between current infection status and intensity of Schistosoma mansoni, Schistosoma japonicum, or Schistosoma mekongi with periportal fibrosis.

Methods: In this systematic review and meta-analysis, we searched the Cochrane Central Register of Controlled Trials, Embase, Global Health, Global Index Medicus, and MEDLINE from database inception to June 18, 2024.

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Cerebral schistosomiasis in a 3-year-old girl due to : a case report.

Front Immunol

December 2024

Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Introduction: Cerebral schistosomiasis is a rare but severe manifestation of infection, often leading to significant neurological impairment. This case report details the clinical presentation, diagnostic challenges, and treatment of a 3-year-old girl with cerebral schistosomiasis in Sichuan, China.

Case Description: A 3-year-old girl from a rural area in Sichuan, China, presented with a 3-month history of unstable walking, left facial paralysis, drowsiness, and intermittent fever.

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Background: Zoonotic schistosomiasis, caused by Schistosoma japonicum, is prevalent in China, the Philippines and Indonesia. Rapid point-of-care (POC) diagnostics are attractive and promising tools for evaluating the efficacy of intervention strategies for schistosomiasis control.

Methodology: The diagnostic potential of five recombinant antigens was tested by enzyme-linked immunosorbent assay (ELISA) using sera from individuals with positive Kato-Katz (KK) results for S.

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Background: Interferon regulatory factor 4 (IRF4) is a crucial member of the IRF family of transcription factors and is pivotal in orchestrating the body's defense against tumors and infections by modulating the differentiation and functionality of immune cells. The role of IRF4 in mice during Schistosoma japonicum infection, as well as the effects of IRF4 deficiency on myeloid-derived suppressor cells (MDSCs), remains inadequately understood.

Methods: Hematoxylin and eosin staining was used to evaluate the pathological damage in different organs of mice following infection with S.

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Impact of water physicochemical properties on the survival of Oncomelania hupensis snails, the intermediate host of Schistosoma japonicum.

BMC Infect Dis

November 2024

National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory On Parasite and Vector Control Technology, Jiangsu Provincial Medical Key Laboratory, Jiangsu Institute of Parasitic Diseases, Wuxi, 214064, Jiangsu, China.

Article Synopsis
  • Schistosoma japonicum relies on Oncomelania hupensis snails for its life cycle, making snail control crucial for reducing schistosomiasis transmission. Research has previously focused on environmental factors affecting snail populations, but the role of water physicochemical properties has been less studied.
  • In a laboratory setting, experiments using river and tap water revealed that infected snails had a significantly higher survival rate in tap water after six months compared to those in river water, while the survival rate for non-infected snails was similar across both water types.
  • Analysis showed that factors like total phosphorus, pH, and biochemical oxygen demand positively impacted the survival of infected snails, while phosphate and total nitrogen posed risks; similar protective
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