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Immunomodulatory Potential of a Bibenzyl-dihydrophenanthrene Derivative Isolated from .
J Nat Prod
January 2025
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Bibenzyls and dihydrophenanthrenes exhibit promising immunomodulatory effects in various human diseases. In this study, we isolated one new dihydrophenanthrene derivative (), two new bibenzyl-dihydrophenanthrene derivatives () along with 12 known compounds (-) from the methanol extract of . These compounds were identified by using physicochemical analyses and spectroscopic methods.
View Article and Find Full Text PDFWhite Matter Injury in Central Nervous System Disorders.
Neuropsychiatr Dis Treat
January 2025
Department of Rehabilitation Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, People's Republic of China.
As the aging process accelerates and living conditions improve, central nervous system (CNS) diseases have become a major public health problem. Diseases of the CNS cause not only gray matter damage, which is primarily characterized by the loss of neurons, but also white matter damage. However, most previous studies have focused on grey matter injury (GMI), with fewer studies on white matter injury (WMI).
View Article and Find Full Text PDFGut Microbiome as Potential Therapeutics in Multiple Sclerosis.
Curr Treat Options Neurol
November 2021
Department of Neurology, Biomedical Science Tower 3, University of Pittsburgh, Suite 7014, 3501 5th Avenue, Pittsburgh, PA 15260, USA.
Purpose Of Review: The gut microbiome is an emerging arena to investigate multiple sclerosis (MS) pathogenesis and potential therapeutics. In this review, we summarize the available data and postulate the feasibilities of potential MS therapeutic approaches that modulate the gut microbiome.
Recent Findings: Growing evidence indicates dysbiosis in the gut bacterial ecosystem in MS.
Fingolimod-associated cryptococcal meningitis in a patient with Multiple Sclerosis: A case report and literature review.
IDCases
January 2025
Department of Infectious Diseases, Osaka City General Hospital, Osaka, Japan.
A 65-year-old woman with Multiple Sclerosis treated with fingolimod developed headaches and convulsions. Cerebrospinal fluid (CSF) culture indicated . A literature review of 20 cases of cryptococcal meningitis indicated that headache was the most common initial symptom, and all cases were positive for serum and/or CSF cryptococcal antigens.
View Article and Find Full Text PDFObjectives: To assess long-term outcomes (up to 10 cycles) of repeated intradetrusor botulinum toxin (BoNT) utilisation in multiple sclerosis (MS) and idiopathic overactive bladder (OAB).
Materials And Methods: This is a retrospective, international, multi-centre, observational cohort study of patients diagnosed with MS and neurogenic OAB and treated with intradetrusor BoNT between January 2005 and January 2020 (just prior to COVID-19 interruption). Dose, efficacy, duration of effect, International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and International Consultation on Incontinence Questionnaire Urinary Incontinence (ICIQ-UI) measures and complication rates were recorded.
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