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Molecular principles of the assembly and construction of a carboxysome shell.
Sci Adv
November 2024
MOE Key Laboratory of Evolution and Marine Biodiversity, Frontiers Science Center for Deep Ocean Multispheres and Earth System & College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China.
Article Synopsis
- * The carboxysome shell contains various protein structures that help concentrate carbon dioxide around the enzyme Rubisco, which is crucial for the carboxylation process.
- * Recent research using cryo-electron microscopy has revealed insights into how these shell proteins assemble, highlighting the importance of the scaffolding protein CsoS2 in forming larger shell structures.
Structural requirements for the specific binding of CRABP2 to cyclin D3.
Structure
December 2024
Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address:
Article Synopsis
- CRABP2 is a protein that transports retinoic acid to the nucleus, where it activates gene transcription by interacting with retinoic acid receptors.
- CRABP2 also binds specifically to cyclin D3, and the binding sites for cyclin D3 and retinoic acid overlap within a specific region of the protein.
- Mutations that disrupt the binding of both cyclin D3 and retinoic acid alter the structure of CRABP2, revealing insights into its function and interaction with cyclin D3 in the context of the CDK4/6 complex.
Laparoscopic but not open surgical skills can be transferred to robot-assisted surgery: A systematic review and meta-analysis.
World J Surg
January 2024
Department of General, Visceral, and Transplantation Surgery, University Hospital of Heidelberg, Heidelberg, Germany.
Background: With an increase in robot-assisted surgery across all specialties, adequate training and credentialing strategies need to be identified to ensure patients safety. The meta-analysis assesses the transferability of technical surgical skills between laparoscopic surgery, open surgery, and robot-assisted surgery.
Design: A systematic search was conducted in Medline, Cochrane Central Register of Controlled Trials, and Web of Science.
Dynamic inter-domain transformations mediate the allosteric regulation of human 5, 10-methylenetetrahydrofolate reductase.
Nat Commun
April 2024
Biosciences Institute, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.
Article Synopsis
- MTHFR is an enzyme that converts folate-derived units into S-adenosyl-L-methionine (SAM), a crucial methyl donor for various biological processes.
- Researchers used cryo-electron microscopy to study human MTHFR in both an active state, where it binds to S-adenosyl-L-homocysteine (SAH), and an inhibited state with dual SAM binding.
- The study reveals how MTHFR's regulatory domain undergoes significant structural changes to inhibit enzyme activity, providing insight into how the enzyme responds to the cell's methylation levels.
Nomina anatomica-unde venient et quo vaditis?
Anat Sci Int
September 2024
Division of Macroscopic and Clinical Anatomy, Gottfried Schatz Research Center, Medical University of Graz, Auenbruggerplatz 25, 8036, Graz, Austria.
As the title indicates, this article deals with the origins of anatomic terminology and its development up to the present day. The first attempt to name anatomical structures in animals and humans date back to Alkmaion, i.e.
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