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Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease. | LitMetric

AI Article Synopsis

Article Abstract

To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2964049PMC
http://dx.doi.org/10.1371/currents.RRN1190DOI Listing

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