Objective: To study the risk prediction for new intracerebral hemorrhage (ICH) with high sensitivity C-reactive protein (hs-CRP) level.
Methods: In a retrospective, nested, case-controlled study, 323 cases of ICH were identified and matched with 646 controls. The hs-CRP levels at baseline were compared between the two groups. The relevance of different hs-CRP levels and the risk of ICH were analyzed.
Results: The ICH group had a higher median hs-CRP levels (1.10 mg/L) as compared with the control group (0.66 mg/L) with significant difference (P<0.01). In addition, the increase of risk associated with hs-CRP levels was primarily observed in the individuals with the highest quartile of hs-CRP levels (>2.12 mg/L). These patients had an increased risk of ICH (OR 2.58, 95%CI 1.77 to 3.76) as compared with those in the lowest quartile (≤0.30 mg/L). Individuals with baseline hs-CRP levels above the specified cut point of 3 mg/L or more and those in the 80th percentile were at a markedly increased risk of ICH (for specified cut point of 3 mg/L, OR 2.26, 95%CI 1.60 - 3.20, P<0.01; for 80th percentile, OR 2.24, 95%CI 1.60 - 3.13, P<0.01, respectively).
Conclusions: Risk of ICH might be predicted with the level of hs-CRP. With the increase of hs-CRP level at baseline, the risk of ICH was increased.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
The relationship between serum vitamin C levels and high-sensitivity C-reactive protein in children.
Sci Rep
December 2024
Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou Key Laboratory of Children's Infection and Immunity, Zhengzhou, 450000, P. R. China.
The relationship between vitamin C nutritional status and inflammation has garnered increasing attention, but studies in younger populations are limited. This study aimed to investigate the association between serum vitamin C and high-sensitivity C-reactive protein (hs-CRP) levels in children and adolescents. A cross-sectional analysis was conducted using data from the National Health and Nutrition Examination Survey (NHANES).
View Article and Find Full Text PDFSystematic review and meta-analysis of colistin plus meropenem therapy for the treatment of nosocomial pneumonia.
Iran J Microbiol
December 2024
Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Background And Objectives: Nosocomial pneumonia caused by multidrug-resistant gram-negative bacteria presents a significant challenge for healthcare systems, as there are limited effective treatments available. This systematic review and meta-analysis aim to investigate the outcomes of colistin plus meropenem combination therapy on nosocomial pneumonia.
Materials And Methods: An exhaustive search of PubMed, Scopus, Web of Science (WOS), and Embase databases was conducted, resulting in the extraction of 5 studies for qualitative assessment and meta-analysis.
Proteomics-Based Soluble Urokinase Plasminogen Activator Receptor Levels Are Associated With Incident Heart Failure Risk.
JACC Adv
January 2025
Emory University School of Medicine, Division of Cardiology, Department of Medicine, Atlanta, Georgia, USA.
Background: Higher soluble urokinase plasminogen activator receptor (suPAR) levels are associated with adverse outcomes in chronic heart failure (HF).
Objectives: The authors assessed the association between proteomics-based suPAR levels and incident HF risk in the general population.
Methods: In 40,418 UK Biobank participants without HF or coronary artery disease at enrollment, the association between Olink-based suPAR levels measured as relative protein expression levels and incident all-cause, ischemic, and nonischemic HF was analyzed by competing-risk regression, while accounting for all-cause death as a competing risk.
Effects of (L.) fruit extract on the profile of hematology of ranchu goldfish ().
Open Vet J
November 2024
Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background: Disease prevention in cultivating ranchu goldfish () can be prevented by giving immunostimulants in the food. One immunostimulant can come from herbs such as calabash fruit ( L.).
View Article and Find Full Text PDFClinical and molecular identification of Newcastle disease virus in naturally infected chicks in Thi-Qar province of Iraq.
Open Vet J
November 2024
Department of Physiology, College of Veterinary Medicine and Surgery, Shatrah University, Shatrah, Thi-Qar, Iraq.
Background: In poultry, despite intense vaccination programs for prevention of Newcastle disease (ND), the ND infection still affects, causing high mortality in most vaccinated flocks.
Aim: This study aimed to determine whether the genetic material of the ND virus has changed and has become incompatible with the vaccines used in Iraq.
Methods: Real-time PCR was used to analyze genetic variation in the fusion (F) and haemaggluatination neuraminidase (HN) genes, as well as mRNA expression changes in inflammatory biomarkers, including C-reactive protein (CRP), interleukin 6, interleukin-1 beta (IL-6, IL-1β), and gamma interferon (IFN-γ).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!