AI Article Synopsis
- Researchers evaluated serum samples from 251 children in endemic areas and 188 hospital outpatients in Ethiopia to measure specific IgG4 antibodies related to Schistosoma mansoni.
- Patients with schistosomiasis (140 individuals) showed significantly higher levels of IgG4 antibodies than normal controls (30 individuals) and those infected with other parasites (114 individuals).
- The study demonstrates that dried blood samples on filter paper can be used for testing and compares this immunoassay method to traditional parasitological diagnostic techniques.
Article Abstract
Sera from 251 children living in endemic areas (Schistosoma mansoni or Schistosoma haematobium) and from 188 hospital outpatients in Ethiopia were evaluated for specific IgG4 antibodies reacting with Schistosoma mansoni adult worm antigen employing an enzyme-immunoassay. Patients with schistosomiasis (n = 140) possessed a significantly higher mean value of specific IgG4 antibodies than normal controls (n = 30) and individuals from different countries who had no schistosomiasis but are infected with other parasites (n = 114). Blood samples dried on filter paper were also acceptable in these test. The use of the test in diagnosis is compared and assessed with parasitological methods.
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