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The Effect of Heat-treated Poultry Pellets and Composted Poultry Litter on E. coli Survival in Southeastern US Soils: Florida and Georgia.
J Food Prot
December 2024
Food Science and Human Nutrition Department, Institute of Food and Agriculture Sciences, University of Florida, Gainesville, FL 32611, United States. Electronic address:
Biological soil amendments of animal origin (BSAAO) are a source of foodborne pathogens that can contaminate fresh produce. This study evaluated the survival of E. coli over 140 d in agricultural soils amended with composted poultry litter (PL), heat-treated poultry pellets (HTPP), or unamended (UN) in Florida (FL) and Georgia (GA).
View Article and Find Full Text PDFAssessing disability progression using the WHODAS 2.0 in multiple sclerosis: Investigating clinical and socio-demographic factors in a large longitudinal cohort study (TONiC-MS).
Mult Scler Relat Disord
December 2024
Walton Centre NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, Merseyside, UK; University of Liverpool, Liverpool, Merseyside, UK.
Background: Identifying influences on disability accumulation in multiple sclerosis (MS), including modifiable factors other than the core features of disease itself, is vital for clinical care, but has often relied on instruments with acknowledged psychometric shortcomings. We model MS disability using the WHO Disability Assessment Schedule (WHODAS) 2.0, a validated measure based on the WHO's biopsychosocial model and sensitive to the breadth of disability-related domains important to people, to investigate the factors associated with its trajectory after diagnosis.
View Article and Find Full Text PDFEvaluating causal associations of chronotype with pregnancy and perinatal outcomes and its interactions with insomnia and sleep duration: a mendelian randomization study.
BMC Pregnancy Childbirth
December 2024
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
Background: Observational studies suggested chronotype was associated with pregnancy and perinatal outcomes. Whether these associations are causal is unclear. Our aims are to use Mendelian randomization (MR) to explore (1) associations of evening preference with stillbirth, miscarriage, gestational diabetes, hypertensive disorders of pregnancy, perinatal depression, preterm birth and offspring birthweight; and (2) differences in associations of insomnia and sleep duration with those outcomes between chronotype preferences.
View Article and Find Full Text PDFA framework for conducting GWAS using repeated measures data with an application to childhood BMI.
Nat Commun
November 2024
Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia.
Genetic effects on changes in human traits over time are understudied and may have important pathophysiological impact. We propose a framework that enables data quality control, implements mixed models to evaluate trajectories of change in traits, and estimates phenotypes to identify age-varying genetic effects in GWAS. Using childhood BMI as an example trait, we included 71,336 participants from six cohorts and estimated the slope and area under the BMI curve within four time periods (infancy, early childhood, late childhood and adolescence) for each participant, in addition to the age and BMI at the adiposity peak and the adiposity rebound.
View Article and Find Full Text PDFInvestigating the Potential Short-term Adverse Effects of the Quadrivalent Human Papillomavirus Vaccine: A Novel Regression Discontinuity Analysis.
Epidemiology
November 2024
From the The National Institute for Health Research Applied Research Collaboration West (NIHR ARC West) at University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom.
Background: Human papillomavirus (HPV) vaccination has been offered in over a hundred countries worldwide (including the United Kingdom, since September 2008). Controversy around adverse effects persists, with inconsistent evidence from follow-up of randomized controlled trials and confounding by indication limiting the conclusions drawn from larger-scale observational studies. This study aims to estimate the association between receiving a quadrivalent HPV vaccine and the reporting of short-term adverse effects and to demonstrate the utility of regression discontinuity design for examining side effects in routine data.
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