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Hepatocellular Carcinoma in Mice Affects Neuronal Activity and Glia Cells in the Suprachiasmatic Nucleus.
Biomedicines
September 2024
Institute of Anatomy II, Medical Faculty, Heinrich Heine University, Moorenstraße 5, 40225 Düsseldorf, Germany.
: Chronic liver diseases such as hepatic tumors can affect the brain through the liver-brain axis, leading to neurotransmitter dysregulation and behavioral changes. Cancer patients suffer from fatigue, which can be associated with sleep disturbances. Sleep is regulated via two interlocked mechanisms: homeostatic regulation and the circadian system.
View Article and Find Full Text PDFThe disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2 mice; a comparison with C57BL/6J and Adar2 mice strains.
Brain Res
March 2024
Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic; National Institute of Mental Health, Klecany, Czech Republic. Electronic address:
Article Synopsis
- Adar2 mice are commonly used to study the effects of reduced RNA editing, specifically relating to the Gria2 subunit of the AMPA receptor, which impacts their circadian rhythms.
- The study found that Gria2 mice lost circadian rhythmicity in the hippocampus when compared to Adar2 mice, indicating a significant effect on their internal clock.
- These findings suggest that the postnatal increase in editing of the Gria2 subunit is important for the circadian clock's development in certain brain areas, raising questions about using Gria2 mice as controls in related experiments.
Methadone administered to rat dams during pregnancy and lactation affects the circadian rhythms of their pups.
J Neurosci Res
November 2023
Department of Physiology, Faculty of Science, Charles University, Prague, Czech Republic.
The circadian clock is one of the most important homeostatic systems regulating the majority of physiological functions. Its proper development contributes significantly to the maintenance of health in adulthood. Methadone is recommended for the treatment of opioid use disorders during pregnancy, increasing the number of children prenatally exposed to long-acting opioids.
View Article and Find Full Text PDFCirculating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure.
Nat Commun
April 2023
Appetite Regulation Laboratory, Asan Institute for Life Science, Seoul, 05505, Korea.
Nicotinamide adenine dinucleotide (NAD) is an essential cofactor of critical enzymes including protein deacetylase sirtuins/SIRTs and its levels in mammalian cells rely on the nicotinamide phosphoribosyltransferase (NAMPT)-mediated salvage pathway. Intracellular NAMPT (iNAMPT) is secreted and found in the blood as extracellular NAMPT (eNAMPT). In the liver, the iNAMPT-NAD axis oscillates in a circadian manner and regulates the cellular clockwork.
View Article and Find Full Text PDFRadiotherapy of the Hepatocellular Carcinoma in Mice Has a Time-Of-Day-Dependent Impact on the Mouse Hippocampus.
Cells
December 2022
Institute of Anatomy II, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225 Düsseldorf, Germany.
Chronic liver diseases including hepatocellular carcinoma (HCC) create a state of chronic inflammation that affects the brain via the liver-brain axis leading to an alteration of neurotransmission and cognition. However, little is known about the effects of HCC on the hippocampus, the key brain region for learning and memory. Moreover, radiotherapy used to treat HCC has severe side effects that impair patients' life quality.
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