AI Article Synopsis
- The study investigated how the spleen affects the body's response to hemorrhagic shock by comparing three groups of pigs: those with intact spleens, those without (splenectomized), and those with their spleens transplanted back (splenic autotransplant).
- Hemorrhagic shock was induced by bleeding out 30% of the pigs' total blood volume, and various cardiovascular and metabolic measures were recorded at different time intervals post-hemorrhage.
- Results showed that pigs without spleens or with transplanted spleens had lower blood parameters and did not recover as well compared to those with intact spleens, suggesting the crucial role of the spleen during shock and highlighting the potential for further research using pigs as a model for
Article Abstract
The spleen is an important organ for hemodynamic compensation during hemorrhagic shock. The aim of the study was to compare the hemodynamic and metabolic responses of sham-operated pigs with intact spleen, splenectomized pigs, and splenic autotransplanted pigs during hemorrhagic shock. Hemorrhagic shock was induced by 30% total blood volume bleed in sham-operated, splenectomized and splenic autotransplanted pigs (n = 20). Cardiopulmonary and metabolic variables were measured before, immediately after, and at 20, 60 and 100 minutes after hemorrhage. Upon hemorrhagic shock induction, body temperature, mean arterial pressure, mean pulmonary arterial pressure, cardiac output, cardiac index and oxygen delivery decreased, while lactate and shock index increased. Hemoglobin and hematocrit were significantly lower in the splenectomized and splenic autotransplant groups as compared with the control group at 60 and 100 minutes after hemorrhage (p < 0.05). Unlike intact spleen, splenic autotransplant could not improve hemodynamic parameters in hemorrhagic shock in pigs. In comparison to mice, rats or dogs, this species could be an interesting investigation model to test new surgical procedures during splenic related hemorrhagic shock, with potential applications in human medicine.
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