AI Article Synopsis
- Mycobacterium tuberculosis, the bacteria causing tuberculosis, is primarily studied in its H37Rv strain for research purposes.
- Comparative genome analysis was conducted between Mycobacterium tuberculosis H37Rv and the human genome to pinpoint essential genes using the Database of Essential Genes (DEG).
- The final results identified 135 essential proteins in H37Rv that do not resemble any human proteins, indicating potential targets for treatment.
Article Abstract
Mycobacterium tuberculosis is the causative agent of the disease, tuberculosis and H37Rv is the most studied clinical strain. We use comparative genome analysis of Mycobacterium tuberculosis H37Rv and human for the identification of potential targets dataset. We used DEG (Database of Essential Genes) to identify essential genes in the H37Rv strain. The analysis shows that 628 of the 3989 genes in Mycobacterium tuberculosis H37Rv were found to be essential of which 324 genes lack similarity to the human genome. Subsequently hypothetical proteins were removed through manual curation. This further resulted in a dataset of 135 proteins with essential function and no homology to human.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951718 | PMC |
| http://dx.doi.org/10.6026/97320630004245 | DOI Listing |
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