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Green synthesis, characterization, antioxidant, interaction with DNA/BSA, and investigation of cytotoxicity against MCF-7 cancer cells of zinc oxide nanoparticles using Hammada scoparia (Pomel) Iljin extract.
Int J Biol Macromol
January 2025
Nuclear Research Centre of Birine, Ain Oussera, Djelfa 17200, Algeria. Electronic address:
There is a need for advanced developments to battle aggressive breast cancer variations and to address treatment resistance. In cancer therapy, ZnO nanoparticles (NPs) possess the ability to selectively and effectively induce apoptosis in cancer cells. There is an urgent necessity to create novel anti-cancer therapies, and recent studies indicate that ZnO nanoparticles have significant promise.
View Article and Find Full Text PDFNurses' Journey Towards Recovery: Describing Suffering During the COVID-19 Pandemic to Present Day.
Int J Ment Health Nurs
February 2025
Duke University School of Nursing, Durham, North Carolina, USA.
The nursing profession has been significantly affected by the COVID-19 pandemic, and nurses continue to suffer emotionally and psychologically. The purpose of this study was to describe the experiences of chronic and ongoing occupational psychological trauma nurses have endured during the COVID-19 pandemic to present day. Eight nurses were interviewed between November 2022 and April 2023.
View Article and Find Full Text PDFImmunotherapy in the Battle Against Bone Metastases: Mechanisms and Emerging Treatments.
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November 2024
Department of Anatomy and Genetics, College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia.
Bone metastases are a prevalent complication in advanced cancers, particularly in breast, prostate, and lung cancers, and are associated with severe skeletal-related events (SREs), including fractures, spinal cord compression, and debilitating pain. Conventional bone-targeted treatments like bisphosphonates and RANKL inhibitors (denosumab) reduce osteoclast-mediated bone resorption but do not directly impact tumor progression within the bone. This review focuses on examining the growing potential of immunotherapy in targeting the unique challenges posed by bone metastases.
View Article and Find Full Text PDFStrategies Used by SARS-CoV-2 to Evade the Innate Immune System in an Evolutionary Perspective.
Pathogens
December 2024
Department of Clinical Laboratory, Institute of Translational Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China.
By the end of 2019, the COVID-19 pandemic, resulting from the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), had diffused widely across the globe, with 770 million infected individuals and over 7 million deaths reported. In addition to its high infectivity and pathogenicity and its rapid mutation rate, the unique capacity of SARS-CoV-2 to circumvent the immune system has also contributed to the widespread nature of this pandemic. SARS-CoV-2 elicits the onset of innate immune system activation and initiates antiviral responses once it has infected the host.
View Article and Find Full Text PDFmRNA-LNP vaccines combined with tPA signal sequence elicit strong protective immunity against .
mSphere
December 2024
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu, China.
is a prominent Gram-negative and encapsulated opportunistic pathogen that causes a multitude of infections such as severe respiratory and healthcare-associated infections. Despite the widespread anti-microbial resistance and the high mortality rate, currently, no clinically vaccine is approved for battling . To date, messenger RNA (mRNA) vaccine is one of the most advancing technologies and are extensively investigated for viral infection, while infrequently applied for prevention of bacterial infections.
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