AI Article Synopsis
- The study compares hydride transfer processes in both the wild-type dihydrofolate reductase and a mutant version (I14A).
- It suggests that the size of the side chain at position 14 impacts how effectively hydrogen tunneling occurs during the enzymatic reaction.
- This modulation of H-tunneling could influence the enzyme's overall efficiency and behavior.
Article Abstract
Comparison of the nature of hydride transfer in wild-type and active site mutant (I14A) of dihydrofolate reductase suggests that the size of this side chain at position 14 modulates H-tunneling.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346287 | PMC |
| http://dx.doi.org/10.1039/c0cc02988b | DOI Listing |
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