AI Article Synopsis

  • This study compares the accuracy of three dose calculation algorithms (Pencil Beam, Anisotropic Analytical, and Collapsed Cone Convolution Superposition) used in intensity-modulated radiation therapy (IMRT) to find differences in radiation dose delivery.
  • The algorithms' dose distributions were analyzed in detail using MATLAB, and the accuracy of their predictions was measured with the γ function, focusing on their impact on dose-volume histograms and probabilities of tumor control and tissue complications.
  • Results showed that the Pencil Beam algorithm often leads to over-dosage in both tumor and lung areas, with significant differences noted in some patients; the effect of these inaccuracies varies between individuals based on tumor location and beam geometry

Article Abstract

The aim of this study was to evaluate the differences in accuracy of dose calculation between 3 commonly used algorithms, the Pencil Beam algorithm (PB), the Anisotropic Analytical Algorithm (AAA), and the Collapsed Cone Convolution Superposition (CCCS) for intensity-modulated radiation therapy (IMRT). The 2D dose distributions obtained with the 3 algorithms were compared on each CT slice pixel by pixel, using the MATLAB code (The MathWorks, Natick, MA) and the agreement was assessed with the γ function. The effect of the differences on dose-volume histograms (DVHs), tumor control, and normal tissue complication probability (TCP and NTCP) were also evaluated, and its significance was quantified by using a nonparametric test. In general PB generates regions of over-dosage both in the lung and in the tumor area. These differences are not always in DVH of the lung, although the Wilcoxon test indicated significant differences in 2 of 4 patients. Disagreement in the lung region was also found when the Γ analysis was performed. The effect on TCP is less important than for NTCP because of the slope of the curve at the level of the dose of interest. The effect of dose calculation inaccuracy is patient-dependent and strongly related to beam geometry and to the localization of the tumor. When multiple intensity-modulated beams are used, the effect of the presence of the heterogeneity on dose distribution may not always be easily predictable.

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http://dx.doi.org/10.1016/j.meddos.2010.03.008DOI Listing

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