AI Article Synopsis
- The study investigated the effects of ultrasound and microbubbles on blood vessel function in 96 male hamsters under various conditions, including ischemia-reperfusion and hyperglycemia.
- Ultrasound treatment reduced inflammation indicators like rolling and adhered leukocytes and increased the diameter of blood vessels in certain conditions.
- Findings suggest that ultrasound might be beneficial for reducing inflammation without increasing unwanted leukocyte adhesion.
Article Abstract
Background: In view of the debate on the safety of using ultrasound associated with microbubbles, we investigated the microvascular effects in situations of potential clinical interest.
Methods: Ultrasound, microbubbles, and their association were evaluated on the cheek pouch microcirculation in 96 male hamsters (n = 6 in each group): control; ischemia-reperfusion, 30 minutes total ischemia followed by reperfusion; hyperinsulinemia and hyperglycemia (substitution of the drinking water by 10% fructose solution for 3 months); and endotoxic shock (induced by Escherichia coli lipopolysaccharide). The heart rate, mean arterial pressure, number of rolling and adhered leukocytes, and arteriolar and venular diameters were analyzed.
Results: Heart rate and mean arterial pressure were lower in the endotoxic shock group than in the control group. Ultrasound alone or associated with microbubbles decreased the number of rolling and adhered leukocytes in the ischemia-reperfusion and hyperinsulinemia and hyperglycemia groups and increased venular diameter in the ischemia-reperfusion group.
Conclusion: The use of ultrasound decreases inflammation. Although it has not been established that pseudo-anaphylaxis can be assessed by intravital microscopy, microbubble administration does not increase venular leukocyte adhesion.
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| http://dx.doi.org/10.1016/j.echo.2010.09.006 | DOI Listing |
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