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Systematically developing a registry of splice-site creating variants utilizing massive publicly available transcriptome sequence data.
Nat Commun
January 2025
Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
Genomic variants causing abnormal splicing play important roles in genetic disorders and cancer development. Among them, variants that cause the formation of novel splice-sites (splice-site creating variants, SSCVs) are particularly difficult to identify and often overlooked in genomic studies. Additionally, these SSCVs are frequently considered promising candidates for treatment with splice-switching antisense oligonucleotides (ASOs).
View Article and Find Full Text PDFStructure factor line shape model gives approximate nanoscale size of polar aggregates in pyrrolidinium-based ionic liquids.
Phys Chem Chem Phys
January 2025
Department of Chemistry and Biochemistry, Northern Illinois University, 1425 W. Lincoln Highway, DeKalb, IL, USA.
Room temperature ionic liquids (RTILs) are interesting due to their myriad uses in fields such as catalysis and electrochemistry. Their properties are intimately related to their structures, yet structural understanding is difficult to achieve. This work presents a derivation of an approximate expression for the radial distribution function, ().
View Article and Find Full Text PDFAtelocollagen-based hydrogel loaded with's extract for treatment of type 2 diabetic wounds.
Biomed Mater
January 2025
Department of Medical Microbiology, Kocaeli Universitesi, Faculty of Medicine Molecular Research and Antibody Laboratory, Kocaeli, 41001, TURKEY.
Diabetes, a chronic metabolic disease, causes complications such as chronic wounds which are difficult to cure. New treatments have been investigated to accelerate the wound healing. In this study, a novel wound dressing from fibroblast-laden atelocollagen-based hydrogel with Cotinus coggygria's extract was developed for diabetic wound healing.
View Article and Find Full Text PDFTaming the Flow with Hyperbranched Polyamides as Melt Modifiers in Polyamide Composites.
Macromol Rapid Commun
January 2025
Department of Advanced Materials Engineering, Chung-Ang University, Anseong, 17546, Republic of Korea.
Transport equipment manufacturers in the automotive and aerospace industries are focused on developing materials that enhance fuel efficiency and reduce carbon dioxide emissions. A significant approach is employing lightweight materials like aluminum, magnesium, and polymer-based composites. Polyamide-based composites, particularly nylon 66, as viable alternatives due to their excellent rigidity, chemical resistance, and thermal stability are investigated to address the limitations of traditional thermosetting resins, which are difficult to recycle and have lengthy molding processes that hinder mass production.
View Article and Find Full Text PDFSuccessful pain control of lymphangioma-suspected lesions in pregnancy with acetaminophen and opioids: A case report and literature review.
J Obstet Gynaecol Res
January 2025
Department of Obstetrics and Gynecology, Takatsuki General Hospital, Takatsuki, Japan.
Lymphangioma causing pain during pregnancy is not widely reported, but surgical treatment was performed in each of the reported cases. In our patient, lesions arose in the retroperitoneal cavity and caused intense pain from 17 weeks of gestation. However, surgical treatment was considered difficult because of the location of the lesion.
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