Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/archsurg.2010.195 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Buparlisib and Paclitaxel in Patients with Head and Neck Squamous Cell Carcinoma: Immunogenomic Biomarkers of Efficacy from the BERIL-1 Study.
Target Oncol
January 2025
Hematology-Oncology Service, Department of Medicine, Centre hospitalier de l'Université de Montréal (CHUM), 1000, rue Saint-Denis, Montreal, QC, Canada.
Background: BERIL-1 was a randomized phase 2 study that studied paclitaxel with either buparlisib, a pan-class I PIK3 inhibitor, or placebo in patients with recurrent or metastatic (R/M) head and neck squamous cell cancer (HNSCC). Considering the therapeutic paradigm shift with immune checkpoint inhibitors (ICIs) now approved in the first-line setting, we present an updated immunogenomic analysis of patients enrolled in BERIL-1, including patients with immune-infiltrated tumors.
Objective: The objective of this study was to identify biomarkers predictive of treatment efficacy in the context of the post-ICI therapeutic landscape.
When sng meets acupuncture -- a paradigm-shift biomarker for translational research.
J Tradit Complement Med
January 2025
Chinese Medicine Research Center, China Medical University, Taichung, Taiwan.
The sensation of sng (pronounced/səŋ/, the Romanization form of or soreness in Taiwanese Southern Min) associated with a composite of unique sensations, is a novel phenotype for acupoint stimulation. It is perceived by test participants but also by experienced practitioners as a sensation of "taking the bait" (by fish when fishing), a characteristic heavy and tight sensation from the needle. Here, we propose that sng is a powerful biomarker for associated with successful manual acupuncture.
View Article and Find Full Text PDFAntigen Specificity: A Fluctuating Aspect in the Development of Clinical Antibodies?
APMIS
January 2025
Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India.
Development of antibodies for clinical use is a complex process involving numerous aspects, with antigen specificity being the most important. Initially, polyclonal antibodies, that can recognize multiple specific and nonspecific antigens (polyreactive), were developed and were very effective in the treatments. Later on, the polyspecificity/polyreactivity of these polyclonal antibodies (binding to multiple antigens) raised concerns about therapeutic efficacy because of their nonspecific interactions and challenges, such as development of immune complexes, batch-to-batch variability.
View Article and Find Full Text PDFThe degree of parallel/serial processing affects stimulus-driven and memory-driven attentional capture: Evidence for the attentional window account.
Atten Percept Psychophys
January 2025
Department of Psychology, Chungnam National University, Daejeon, Republic of Korea.
The issue of whether a salient stimulus in the visual field captures attention in a stimulus-driven manner has been debated for several decades. The attentional window account proposed to resolve this issue by claiming that a salient stimulus captures attention and interferes with target processing only when an attentional window is set wide enough to encompass both the target and the salient distractor. By contrast, when a small attentional window is serially shifted among individual stimuli to find a target, no capture is found.
View Article and Find Full Text PDFHonesty threshold affects individuals' resistance to monetary temptations.
Sci Rep
January 2025
School of Psychology, South China Normal University, Guangzhou, 510631, China.
This study investigated whether honesty is a stable trait or varies depending on situational factors. Using a coin flip guessing paradigm with monetary rewards, 33 participants completed trials with rewards ranging from 0.01 to 3 yuan.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!