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Effects of β-Blockers on the Outcomes in Patients With Pulmonary Arterial Hypertension Stratified by the Presence of Comorbid Conditions: A Multicenter Prospective Cohort Study (BNP-PL).
Chest
November 2024
Department of Cardiac and Vascular Diseases, John Paul II Hospital, Krakow, Poland; Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Krakow, Poland. Electronic address:
Background: Current guidelines do not recommend β-blockers in pulmonary arterial hypertension (PAH) unless indicated by comorbidities. However, the evidence regarding the role of β-blockers in PAH is contradictory.
Research Question: What are the effects of β-blockers on clinical outcomes in patients newly diagnosed with PAH, and how do these outcomes differ based on the presence of cardiovascular comorbidities that are standard indications for β-blocker use?
Study Design And Methods: We analyzed data from 806 patients newly diagnosed with PAH enrolled prospectively in the Database of Pulmonary Hypertension in the Polish Population (BNP-PL).
Epidemiology of supplemental oxygen in patients with pulmonary hypertension.
Respirology
January 2025
Department of Pulmonary Medicine, Hospital Clínic, University of Barcelona, Barcelona, Spain.
Background And Objective: Patients with pulmonary hypertension (PH) may present with hypoxaemia at rest or during daily activities. There is no epidemiological data on the prescription of long-term oxygen therapy (LTOT) in patients with PH. The study sought to analyse the prevalence and incidence of LTOT prescription among patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH) in Spain and to determine predictors for this prescription.
View Article and Find Full Text PDFPerceptions of Exposure and Mask Use in Wildland Firefighters.
Toxics
August 2024
Division of Preventive Medicine, University of Alberta, Edmonton, AB T6G 2T4, Canada.
Wildland firefighters are exposed to airborne particulates, polycyclic aromatic hydrocarbons (PAHs), and other hazardous substances. Respiratory protection is indicated, but information is lacking on the tasks and conditions for which mask wearing should be advised. Studies to assess respiratory protection in wildland firefighters were carried out in western Canada in 2021 and 2023.
View Article and Find Full Text PDFMaternal exposure to polycyclic aromatic hydrocarbons during pregnancy and timing of pubertal onset in a longitudinal mother-child cohort in rural Bangladesh.
Environ Int
July 2024
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. Electronic address:
Background: In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined their impact on pubertal development and results have been heterogenous.
Objective: To explore if maternal PAH exposure during pregnancy was associated with the offspring's timing of pubertal onset.
Methods: We studied 582 mother-daughter dyads originating from a population-based cohort in a rural setting in Bangladesh.
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