The PRINT(®) (pattern replication in non-wetting templates) process has been developed as a simple, gentle way to pattern films or generate discrete particles in arrays out of either pure biological materials or biomolecules encapsulated within polymeric materials. Patterned films and particle arrays can be fabricated in a wide array of sizes and shapes using Fluorocur(®) (a UV-curable perfluoropolyether polymer) from the nanometer to micron scale.
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Since its introduction, vaccination has heavily improved health outcomes. However, implementing vaccination efforts can be challenging, particularly in low and middle-income countries with warmer climates. Microneedle technology has been developed for its simple and relatively painless applications of vaccines.
View Article and Find Full Text PDFPolymeric Microneedles for Transdermal Delivery of Human Placental Tissue for the Treatment of Osteoarthritis.
Macromol Biosci
December 2024
Faculty of Pharmacy, M S Ramaiah University of Applied Sciences, Bengaluru, Karnataka, 560054, India.
Biologics targeting matrix-degrading proteases, cartilage repair, and inflammation are emerging as promising approaches for osteoarthritis (OA) treatment. Recent research highlights biologic-human placental tissue (HPT) as a potential OA therapy due to its biocompatibility, abundant protein biofactors, and ability to reduce cartilage degradation by suppressing protease expression. Microneedles (MNs) are receiving growing attention for enhancing transdermal delivery of biologics as an alternative to conventional subcutaneous injections.
View Article and Find Full Text PDFProfiling paracrine interactions between hypoxic and normoxic skeletal muscle tissue in a microphysiological system fabricated from 3D printed components.
Lab Chip
December 2024
Alfred E. Mann Department of Biomedical Engineering, USC Viterbi School of Engineering, University of Southern California, 1042 Downey Way, DRB 140, Los Angeles, CA 90089, USA.
Disrupted blood flow in conditions such as peripheral artery disease and critical limb ischemia leads to variations in oxygen supply within skeletal muscle tissue, creating regions of poorly perfused, hypoxic skeletal muscle surrounded by regions of adequately perfused, normoxic muscle tissue. These oxygen gradients may have significant implications for muscle injury or disease, as mediated by the exchange of paracrine factors between differentially oxygenated tissue. However, creating and maintaining heterogeneous oxygen landscapes within a controlled experimental setup to ensure continuous paracrine signaling is a technological challenge.
View Article and Find Full Text PDFFabrication and mechanical/biological evaluations of dissolving bird-bill microneedle arrays.
Drug Deliv Transl Res
December 2024
Department of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka, Fukuoka, 820-8502, Japan.
Article Synopsis
- Coated microneedles (MNs) face challenges like limited drug capacity, difficulty in skin penetration, and clogging risk, prompting the development of a dissolving bird-bill MN (dBB MN) designed with a vertical groove for better functionality in drug delivery.
- The study explored the fabrication of dBB MN arrays using various hydrogel compositions, with optimal results at 25% PVP, demonstrating effective skin penetration and controlled dissolution of the needles for drug release.
- The experiments indicated that insulin-loaded dBB MNs significantly reduced blood glucose levels in diabetic rats, showcasing their potential as a less invasive drug delivery method with high promise for improving treatment access and adherence, especially in low-resource environments.
Sodium Alginate Microneedles Loaded with Vancomycin for Skin Infections.
J Funct Biomater
October 2024
School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK.
Background: Skin and soft tissue infections (SSTIs) present significant treatment challenges. These infections often require systemic antibiotics such as vancomycin, which poses a risk for increased bacterial resistance. Topical treatments are hindered by the barrier function of the skin, and microneedles (MNs) offer a promising solution, increasing patient compliance and negating the need for traditional needles.
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