In this Letter we present the first (to our knowledge) demonstration of material modification using tightly focused single femtosecond laser vortex pulses. Double-charge femtosecond vortices were synthesized with a polarization-singularity beam converter based on light propagation in a uniaxial anisotropic medium and then focused using moderate- and high-NA optics (viz., NA=0.45 and 0.9) to ablate fused silica and soda-lime glass. By controlling the pulse energy, we consistently machine micrometer-size ring-shaped structures with <100nm uniform groove thickness.
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http://dx.doi.org/10.1364/OL.35.003417 | DOI Listing |
Front Neurosci
December 2024
German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
Background: Extracellular vesicles are easily accessible in various biofluids and allow the assessment of disease-related changes in the proteome. This has made them a promising target for biomarker studies, especially in the field of neurodegeneration where access to diseased tissue is very limited. Genetic variants in the LRRK2 gene have been linked to both familial and sporadic forms of Parkinson's disease.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Environmental Engineering, Rajamangala University of Technology Lanna, Chiang Mai, 50300, Thailand.
This study aimed at developing a sustainable waste management from poultry farm by integrating microalgae cultivation with the anaerobic digestion effluent of chicken wastes (ADEC). The analysis was focused on system performance, resource recovery and environmental impact of microalgal biomass-derived added value products. Laboratory-scale of three different systems, i.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Optics Research Group, Delft University of Technology, Department of Imaging Physics, Lorentzweg 1, 2628CJ Delft, The Netherlands.
Chiral objects are abundant in nature, and although the enantiomers have almost identical physical properties apart from their handedness, they can exhibit significantly different chemical properties and biological functions. This underscores the importance of sorting chiral substances. In this Letter, we demonstrate that chirality-sorting optical force pairs can be inversely generated in a tightly focused Gaussian beam by tailoring the input polarization state.
View Article and Find Full Text PDFInterdiscip Sci
December 2024
Institutes of Physical Science and Information Technology, Anhui University, Hefei, 230601, Anhui, China.
High-throughput sequencing has exponentially increased peptide sequences, necessitating a computational method to identify multi-functional therapeutic peptides (MFTP) from their sequences. However, existing computational methods are challenged by class imbalance, particularly in learning effective sequence representations. To address this, we propose PSCFA, a prototypical supervised contrastive learning with a feature augmentation method for MFTP prediction.
View Article and Find Full Text PDFJ Mater Chem B
December 2024
Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
Biomolecular condensates (BCs) are crucial membraneless organelles formed through the process of liquid-liquid phase separation (LLPS) involving proteins and nucleic acids. These LLPS processes are tightly linked with essential cellular activities. Stress granules (SGs), functioning as cytoplasmic BCs, play indispensable roles in maintaining cellular homeostasis and are implicated in diseases like cancers and neurodegenerative disorders.
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