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Cardioprotective effects of the electrolyte solution sterofundin and the possible underlying mechanisms.
Front Pharmacol
January 2025
Department of Anesthesiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Sterofundin (SF) is one of the most widely used electrolyte solutions in almost all areas of medicine, with particular importance in intensive care. It provides powerful correction of acid-base imbalances, ion fluctuations, and impaired energy metabolism, which are the three most important characteristics after myocardial infarction (MI). However, whether and how SF protects the heart from post-MI damage are largely unknown.
View Article and Find Full Text PDFFluorescent Polymers via Coordination of -Terpyridine Ligands with Transition Metals and Their pH Response Properties.
Polymers (Basel)
December 2024
Department of Organic and Polymer Chemistry, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Stimulus-responsive luminescent materials are pivotal in the field of sensing. Fluorescent transition metal complexes with a charge transfer excited state, especially terpyridine-coordinated polymers, are of particular interest due to their tunable emission. In this paper, a novel bis-terpyridine ligand was synthesized and assembled into a coordination polymer, which showed intense visible light absorption and fluorescence emission in the solid state that could be regulated by an acidic or basic pH.
View Article and Find Full Text PDFConstruction of predictive model for the risk of acute lactic acidosis in patients with ischemic stroke during the ICU stay: A study based on the medical information Mart for intensive care database.
J Clin Neurosci
January 2025
Department of Neurology, Beijing Shunyi Hospital, Beijing 101300, PR China. Electronic address:
Background: This study aims to identify the factors influencing the risk of lactic acidosis (LA) in patients with ischemic stroke (IS) and to develop a predictive model for assessing the risk of LA in IS patients during their stay in the intensive care unit (ICU).
Methods: A retrospective cohort design was employed, with data collected from the Medical Information Mart for Intensive Care (MIMIC)-III and MIMIC-IV databases spanning from 2001 to 2019. LA was defined as pH < 7.
Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective.
Sci Rep
January 2025
NHC Key Laboratory of Nuclear Technology Medical Transformation, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, China.
This study aims to explore the relationship between the albumin-corrected anion gap (ACAG) and short- and long-term all-cause mortality (ACM) in patients with acute pancreatitis (AP) managed in the intensive care unit (ICU). We conducted a retrospective analysis utilizing data extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. This study sought to investigate the correlation between ACAG and ACM among patients diagnosed with AP across various disease stages.
View Article and Find Full Text PDFTailoring Mesalazine Nanosuspension Using Chitosan Polyelectrolyte Complexes with Alginate and Alginate/Hydroxypropyl-Methylcellulose Phthalate.
Pharmaceutics
November 2024
Faculty of Pharmaceutical Science, UNESP-São Paulo State University, Rodovia Araraquara-Jaú, Km 01, Araraquara 14801-902, Brazil.
: This study evaluated how the relative proportion of chitosan (CS) to the polyanions alginate (ALG) and hydroxypropyl-methylcellulose phthalate (HP) affects the colloidal properties of mesalazine (MSZ) nanosuspensions as a strategy to produce particles with specific characteristics. : Nanosuspensions were prepared using a bottom-up approach based on acid-base reactions and were modified with CS in a binary mixture with ALG or a ternary mixture with ALG and HP. The particle size, polydispersity index (PDI), zeta potential, morphology, and drug association efficiency were analyzed.
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