Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2214/AJR.10.4539 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Biomarkers.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.
Background: There is a strong link between tau and progression of Alzheimer's disease (AD), necessitating an understanding of tau spreading mechanisms. Prior research, predominantly in typical AD, suggested that tau propagates from epicenters (regions with earliest tau) to functionally connected regions. However, given the constrained spatial heterogeneity of tau in typical AD, validating this connectivity-based tau spreading model in AD variants with distinct tau deposition patterns is crucial.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Instituto Neurológico de Colombia, Medellin, Antioquia, Colombia.
Background: This study examines an exceptional case of CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a hereditary cerebrovascular disease caused by a mutation in the notch3 gene. In contrast to typical cases manifesting before the age of 50 with migraines, this report highlights an atypical presentation in a 70-year-old woman with no history of migraines nor cognitive impairment.
Method: The patient, with a history of type 2 diabetes, hypothyroidism, and dyslipidemia, was initially treated for cognitive impairment and behavioral changes under suspicion of autoimmune encephalitis.
Biomarkers.
Alzheimers Dement
December 2024
Alzheimer Center Amsterdam, Amsterdam UMC, Amsterdam, Netherlands.
Background: Tau-PET is a diagnostic tool with high sensitivity and high specificity for discriminating Alzheimer Disease (AD) dementia from other neurodegenerative disorders in well-controlled research environments. The role of tau-PET in "real-world" clinical practice, however, remains to be established. We hypothesize that tau-PET will lead to some changes of the pre-PET clinical diagnosis and will improve diagnostic certainty and patient management in patients with considerable diagnostic uncertainty.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Università degli studi di Genova, Genova, Liguria, Italy.
Background: Alzheimer's disease (AD) is the most common form of dementia, predominantly manifesting as amnestic impairment. However, atypical presentations such as logopenic variant of primary progressive aphasia (lvPPA), posterior cortical atrophy (PCA), corticobasal syndrome (CBS) and frontal AD pose diagnostic challenges. This study presents preliminary data from a retrospective analysis investigating brain functional differences between typical and atypical AD forms.
View Article and Find Full Text PDFBackground: In daily clinical practice, we often encounter cases with atypical symptoms and imaging findings, even among those diagnosed with Alzheimer's disease. Amyloid PET and cerebrospinal fluid examinations were performed in such non-typical cases and young cases.
Method: A total of 85 patients underwent both amyloid PET and cerebrospinal fluid examinations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!