Paeonol, the main active component isolated from Moutan Cortex, possesses extensive pharmacological activities such as anti-inflammatory, anti-allergic, and immunoregulatory effects. In the present study, we examined the effects of paeonol on airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. BALB/c mice sensitized and challenged with ovalbumin were administered paeonol intragastrically at a dose of 100 mg/kg daily. Paeonol significantly suppressed ovalbumin-induced airway hyperresponsiveness to acetylcholine chloride. Paeonol administration significantly inhibited the total inflammatory cell and eosinophil count in bronchoalveolar lavage fluid. Treatment with paeonol significantly enhanced IFN-γ levels and decreased interleukin-4 and interleukin-13 levels in bronchoalveolar lavage fluid and total immunoglobulin E levels in serum. Histological examination of lung tissue demonstrated that paeonol significantly attenuated allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. These data suggest that paeonol exhibits anti-inflammatory activity in allergic mice and may possess new therapeutic potential for the treatment of allergic bronchial asthma.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1139/y10-077 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Synthesis, anti-oomycete and anti-fungal activities of novel paeonol ester derivatives containing a schiff base.
Nat Prod Res
December 2024
Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticultrue and Plant Protection, Henan University of Science and Technology, Luoyang, China.
To discover biorational natural product-based pesticides, a series of paeonol ester derivatives containing a Schiff base (, , , and ) were prepared, and their structures were well characterised by H NMR and HRMS. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural diseases, and we assessed. Amongst evaluated compounds, 1) Compounds and displayed good anti-oomycete against , with EC values of 116.
View Article and Find Full Text PDFAntifungal activity of paeonol against by disrupting the cell membrane and the application on cherry tomato preservation.
Front Microbiol
December 2024
School of Public Health, Xuzhou Medical University, Xuzhou, China.
may cause gray mold in fruits and vegetables. Paeonol, an active component of traditional Chinese medicine, could suppress various microbial growth. However, reports on its effect on have not yet been documented.
View Article and Find Full Text PDFAnti-sepsis effects of Dahuang Mudan decoction and its disassembled prescriptions.
J Ethnopharmacol
December 2024
School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai, 200433, China; The Center for Fungal Infectious Diseases Basic Research and Innovation of Medicine and Pharmacy, Ministry of Education, Shanghai, 200433, China. Electronic address:
Article Synopsis
- Dahuang Mudan decoction (DMD) is a traditional Chinese medicine used to treat infectious diseases, and this study aims to evaluate its effects on septic mice and understand its mechanisms.
- Various tests, including sepsis models and blood tests, showed that DMD and its components significantly improved survival rates and reduced organ damage in septic mice, similar to a positive control drug (Xuebijing injection).
- The study concluded that DMD and its ingredients work by reducing inflammation and coagulation activation, suggesting a promising therapeutic potential for sepsis treatment.
Paeonol inhibits ACSL4 to protect chondrocytes from ferroptosis and ameliorates osteoarthritis progression.
J Orthop Translat
January 2025
Department of Rehabilitation Science, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China.
Background: Discovering an inhibitor for acyl-CoA synthetase long-chain family member 4 (ACSL4), a protein that triggers cell injury via ferroptosis, presents potential to minimize cellular damage. This study investigates paeonol (PAE), a traditional Chinese herbal medicine, as an ACSL4 inhibitor to prevent chondrocyte ferroptosis and protect against osteoarthritis (OA).
Methods: We conducted experiments using mouse chondrocytes treated with PAE to mitigate ferroptosis induced by Interleukin-1 Beta (IL-1β) or ferric ammonium citrate (FAC), examining intracellular ferroptotic indicators, cartilage catabolic markers, and ferroptosis regulatory proteins.
Discovering the Bioactive Compounds Binding to α-Adrenergic Receptor in Guizhi Fuling Formula and Revealing Their Interactions by Immobilizing the Receptor Through Colicin L7 DNase/Immunity Protein 7 Ultra-Affinity System.
J Sep Sci
December 2024
Engineering Research Center of Tibetan Medicine Detection Technology, Ministry of Education, Xizang Minzu University, Xianyang, P. R. China.
Article Synopsis
- The study investigates Guizhi Fuling Formula (GFF) and α-adrenergic receptors (α-AR) using a novel method involving Colicin L7 DNase (CL7) and its immune protein (Im7) for immobilizing α-AR to a column.
- The immobilization resulted in a stable α-AR column, facilitating the screening of active compounds in GFF, leading to the identification of paeoniflorin, cinnamic acid, and paeonol.
- Notably, cinnamic acid and paeonol bind to the same site on α-AR as the drug tamsulosin, demonstrating the potential of this method for rapid analysis of functional compounds from
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!