AI Article Synopsis
- The study aimed to evaluate the effectiveness of contrast-enhanced ultrasound (CEUS) in diagnosing focal liver lesions (FLLs) by comparing its results to standard diagnostic methods like histopathology, CT, and MRI.
- The research involved 73 patients with 82 FLLs, where CEUS effectively identified 43 malignant lesions and 29 benign lesions, achieving a sensitivity of 86.0% and specificity of 90.6%.
- The findings suggest that CEUS is a promising diagnostic tool for distinguishing between malignant and benign liver lesions, particularly when other imaging options are not suitable.
Article Abstract
Purpose: The purpose of this study was to assess the diagnostic accuracy of our early experience with contrast-enhanced ultrasound (CEUS) in the characterisation of focal liver lesions (FLLs) using histopathology, contrast-enhanced computed tomography (CT), magnetic resonance imaging (MRI) or other imaging follow-up as the standard of reference.
Materials And Methods: Seventy-three patients with 82 FLLs who underwent liver CEUS from January 2006 to December 2008 were retrospectively reviewed. CEUS was performed with up to 4.8 mL of SonoVue® (Bracco, Milan, Italy) using a low mechanical index mode. The CEUS findings were compared with histopathology, or where histopathology was not available, clinical and imaging follow-up over at least 12 months was used as the standard of reference.
Results: Of the 82 FLLs, 50 were malignant and 32 were benign at final diagnosis. CEUS correctly identified 43 malignant FLLs, with final diagnosis confirmed by histopathology in 13 lesions and clinico-radiological follow-up in 30 lesions. Twenty-nine lesions were correctly identified as benign on CEUS, with all these lesions confirmed on clinico-radiological follow-up. CEUS demonstrated a sensitivity of 86.0% and a specificity of 90.6% in the characterisation of liver lesions as malignant, with an overall accuracy of 87.8% (P < 0.05).
Conclusion: Our early experience has shown that CEUS can be accurate in differentiating malignant from benign FLLs and may become a useful first-line imaging tool where CT or MRI are not available or contra-indicated.
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| http://dx.doi.org/10.1111/j.1754-9485.2010.02195.x | DOI Listing |
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