Prenatal diagnosis of a true knot of the umbilical cord is often an incidental observation at ultrasound with a difficult differential diagnosis between true and false knots. Furthermore, little is known about the optimal management of these cases. We report the importance of color Doppler and four-dimensional ultrasound for the differential diagnosis in the case of true cord knot and the role of Doppler flow velocimetry in the management of that case.
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http://dx.doi.org/10.1002/jcu.20757 | DOI Listing |
Front Immunol
January 2025
Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY, United States.
Introduction: The immune compartment within fetal chorionic villi is comprised of fetal Hofbauer cells (HBC) and invading placenta-associated maternal monocytes and macrophages (PAMM). Recent studies have characterized the transcriptional profile of the first trimester (T1) placenta; however, the phenotypic and functional diversity of chorionic villous immune cells at term (T3) remain poorly understood.
Methods: To address this knowledge gap, immune cells from human chorionic villous tissues obtained from full-term, uncomplicated pregnancies were deeply phenotyped using a combination of flow cytometry, single-cell RNA sequencing (scRNA-seq, CITE-seq) and chromatin accessibility profiling (snATAC-seq).
J Med Syst
January 2025
Department of Pain Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA.
Effective referral triaging enhances patient service outcomes, experience and access to care especially for specialized procedures. This study presents the development and implementation of an automated triaging system to predict patients who would benefit from Spinal Cord Stimulation (SCS) procedure for their pain management. The proposed triage system aims to improve the triage process by reducing unnecessary appointments before SCS assessment, ensuring appropriate pain management care.
View Article and Find Full Text PDFArch Dis Child Fetal Neonatal Ed
January 2025
Department of Neonatology, The National Maternity Hospital, Dublin, Ireland.
Background: The Neonatal Resuscitation Program recommends direct laryngoscopy (DL) as the primary method for neonatal intubation. Video laryngoscopy (VL) is suggested as an option, particularly for training novice operators or for intubating infants with difficult airways. The programme outlines specific steps for intubation, including managing the external environment and techniques for visualising key anatomical landmarks.
View Article and Find Full Text PDFCureus
January 2025
Anesthesiology and Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, NLD.
When a difficult airway is anticipated, awake tracheal intubation can be considered. Usually, low doses of sedatives are administered during this procedure for minimal sedation and anxiolysis, such as midazolam and remifentanil. The newly developed ultra-short-acting benzodiazepine remimazolam has a pharmacokinetic profile that is more suitable for titration during awake tracheal intubation than the long-acting midazolam.
View Article and Find Full Text PDFTaiwan J Obstet Gynecol
January 2025
Department of Obstetrics, Fujian Maternity and Child Health Hospital, Fuzhou 350000, Fujian, China. Electronic address:
Objective: To investigate the pregnancy outcomes and independent risk factors associated with true knots of the umbilical cord (TKUC).
Materials And Methods: This retrospective study included 8140 deliveries at Fujian Maternal and Child Health Hospital from 2017 to 2021. Mothers and newborns diagnosed with TKUC were included in the TKUC group, while the others were included in the control group.
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