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Unravelling Secondary Brain Injury: Insights from a Human-Sized Porcine Model of Acute Subdural Haematoma.
Cells
December 2024
Institute of Anaesthesiologic Pathophysiology and Process Development, University Hospital Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
Article Synopsis
- Traumatic brain injury (TBI) is a leading cause of death, complicating the development of effective therapies due to the unique nature of each injury.
- Clinical questions regarding the benefits of measuring intracranial pressure, cerebral perfusion pressure, and surgical interventions remain largely unanswered.
- This study focused on acute subdural hematoma in a porcine model to better understand secondary brain injury and the effects of different injury patterns on outcomes, highlighting the need for comprehensive models to improve TBI treatment translation.
Fresh vs. frozen: pregnancy outcomes and treatment efficacy between fresh embryo transfer vs. untested freeze-all cycles.
F S Rep
December 2024
Department of Obstetrics and Gynecology, University of South Florida, Morsani College of Medicine, Tampa, Florida.
Objective: To compare pregnancy outcomes after single blastocyst embryo transfer among patients whose first autologous embryo transfer was either a fresh embryo transfer or a frozen embryo transfer (FET) after a freeze-all, in the absence of preimplantation genetic testing for aneuploidy (PGT-A).
Design: A multicenter retrospective cohort analysis.
Setting: National multicenter fertility practice.
Spatial distribution of tree-related microhabitats in a primeval mountain forest: From natural patterns to landscape planning and forest management recommendations.
Sci Total Environ
January 2025
Department of Forest Biodiversity, Faculty of Forestry, University of Agriculture, al. 29 Listopada 46, 31-425 Kraków, Poland. Electronic address:
Tree-related Microhabitats (TreMs) are essential for sustaining forest biodiversity. Although TreMs represent ephemeral resources that are spread across the landscape, their spatial distribution within temperate forests remains poorly understood. To address this knowledge gap, we conducted a study on 90 sample plots (0.
View Article and Find Full Text PDFThe Influence of Basal Medium on Polyphenol Accumulation in Shoot Cultures of and .
Molecules
December 2024
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.
Plants of the genus, known for their rich phytochemical profiles, are used in traditional Chinese, Korean, Japanese, and Indian medicine to treat various ailments, including inflammation, hypertension, diabetes, hyperlipidemia, and cancer. Due to the limited natural availability of these plants, there is a growing interest in utilizing in vitro culture techniques to produce their bioactive compounds sustainably. In this study, the effects are compared of Murashige and Skoog (MS), Woody Plant medium (WP), Gamborg B5 (B5), and Schenk and Hildebrandt (SH) basal media on growth, biomass accumulation, and polyphenolic compound production in shoot cultures of and .
View Article and Find Full Text PDFSynergistic Effects and Mechanisms of Action of Rutin with Conventional Antibiotics Against .
Int J Mol Sci
December 2024
Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China.
Rutin is a widely known plant secondary metabolite that exhibits multiple physiological functions. The present study focused on screening for synergistic antibacterial combinations containing rutin, and further explored the mechanisms behind this synergy. In vitro antibacterial test results of rutin showed that the ranges of minimum inhibitory concentration (MIC) and Minimum bactericidal concentration (MBC) are 0.
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