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[Important changes to the 2022 WHO classification of testicular tumours : A guide for diagnostics].

Pathologie (Heidelb)

January 2025

Institut für Pathologie, Universitätsmedizin Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Deutschland.

The 5th Edition of the "WHO Classification of Tumours: Urinary and Male Genital Tumours" introduces several significant updates to the classification of testicular tumours. These updates include revised terminology for special germ cell tumour subtypes (neuroectodermal and neuroendocrine tumours) of the testis. Additionally, the signet-ring stromal tumour and myoid gonadal stromal tumour have been introduced as distinct entities within the sex-cord stromal tumours.

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Myopericytoma is a rare benign smooth-muscle cell neoplasm of the subcutaneous soft tissues that is primarily found in young adults with a male predominance. We present the clinical, radiologic, and histopathologic features of a longstanding myopericytoma of the hand. We emphasize the features that help the radiologist and pathologist to accurately characterize this entity.

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Introduction: Perivascular Epithelioid Cell tumor (PEComa) is a rare mesenchymal neoplasm characterized by the co-expression of melanocytic and myoid markers. While PEComas can arise in diverse anatomical sites, gastric PEComas are exceedingly rare, with merely nine cases documented in the extant literature.

Case Presentation: Herein, we have presented a case of gastric PEComa in a 65-year-old male patient who exhibited a 3-year history of epigastric pain, with notable exacerbation in the two months prior to diagnosis.

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Myopericytoma is a rare perivascular myoid neoplasm that typically arises in the dermis or subcutaneous tissue, with an intravascular variant also reported. We present a case of an elderly man with a subcutaneous nodule in his lower leg that had persisted for four decades, accompanied by pain in the last several years. Imaging revealed a 20-mm elongated subcutaneous nodule along with a similar intraosseous lesion in the ipsilateral fibula.

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Background: Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal neoplasm that predominantly affects the kidney and uterus. The occurrence of this tumor in the liver, particularly with simultaneous involvement of the liver and kidney, is exceedingly uncommon. Pathological diagnosis is the gold standard.

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