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Population pharmacokinetics and exposure-response analysis of durvalumab in combination with gemcitabine and cisplatin in patients with advanced biliary tract cancer.
Cancer Chemother Pharmacol
January 2025
Clinical Pharmacology & Quantitative Pharmacology, BioPharmaceuticals R&D, AstraZeneca, Waltham, MA, USA.
Purpose: Durvalumab in combination with gemcitabine/cisplatin has shown a favorable benefit-risk profile in the TOPAZ-1 study for advanced biliary tract cancers (BTC). This analysis evaluated the population pharmacokinetics (PopPK) of durvalumab, and exposure-response for efficacy and safety (ERES) of TOPAZ-1.
Methods: The PopPK model for durvalumab was updated using data from 5 previously analysed studies and TOPAZ-1.
Analytical model for helical particle array assessment for EMI shielding applications.
Sci Rep
January 2025
School of Electrical Engineering, University of Tehran, Tehran, 14179-35840, Iran.
This paper introduces an analytical method for studying power transmission through an infinite array of helical-shaped metal particles in a lossy dielectric medium. While the assessment of composite slabs' transmitted power has been extensively researched in the electromagnetic interference (EMI) shielding field, many studies lack an adequate problem description. The primary inadequacy of these studies is the need for an analytical framework.
View Article and Find Full Text PDFTransformer-based neural speech decoding from surface and depth electrode signals.
J Neural Eng
January 2025
Electrical and Computer Engineering Department, New York University, 370 Jay Street, Brooklyn, New York, New York, 10012-1126, UNITED STATES.
This study investigates speech decoding from neural signals captured by intracranial electrodes. Most prior works can only work with electrodes on a 2D grid (i.e.
View Article and Find Full Text PDFPhospholipid Profiles in Mushrooms: A Review of Extraction, Analysis, and Functional Applications.
Int J Med Mushrooms
January 2025
Division of Systematic Forest and Forest Products Sciences, Department of Agro-Environmental Sciences, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka, Japan.
Mushrooms are widely recognized for their rich nutritional profile and diverse array of bioactive compounds, including proteins, polysaccharides, and secondary metabolites, which contribute to various health benefits. Among these compounds, phospholipids stand out due to their essential role in cellular processes and their potential applications in food, nutraceuticals, and pharmaceuticals. This review comprehensively examines the phospholipid composition in mushrooms, highlighting the methods of analysis, and delving into their functional applications.
View Article and Find Full Text PDFEffect of condensed heat acclimation on thermophysiological adaptations, hypoxic cross-tolerance, exercise performance and de-acclimation.
J Appl Physiol (1985)
January 2025
Extreme Environments Laboratory, School of Psychology, Sport and Health Sciences, University of Portsmouth, UK.
Short duration heat acclimation (HA) (≤5 daily heat exposures) elicits incomplete adaptation compared to longer interventions, possibly due to the lower accumulated thermal 'dose'. It is unknown if matching thermal 'dose' over a shorter timescale elicits comparable adaptation to a longer intervention. Using a parallel-groups design, we compared: i) 'condensed' HA (CHA; =17 males) consisting of 4×75 min∙day heat exposures (target rectal temperature ()=38.
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