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Pleomorphic adenoma (PA) is a benign salivary gland tumor with diverse cytomorphological and architectural features, typically presenting biphasic ductal structures within a chondromyxoid matrix. We report a unique case of PA where dense lymphoid infiltration disrupted these structures, resulting in duct-like slit structures lined with a single layer of spindle cells, lacking the biphasic pattern. These spindle cells demonstrated myoepithelial nature, confirmed by positive immunostaining for pan-cytokeratin, S100 protein, and calponin.
View Article and Find Full Text PDF[Clinicopathological and molecular characteristics of microsecretory adenocarcinoma in salivary gland].
Zhonghua Bing Li Xue Za Zhi
October 2024
Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.
To investigate the clinicopathological, immunohistochemical, and molecular genetic characteristics of microsecretory adenocarcinoma (MSA) of the salivary gland, and to improve the understanding of this rare tumor. Cases originally diagnosed as MSA at the Department of Oral Pathology, the Ninth People's Hospital of Shanghai Jiao Tong University School of Medicine were retrospectively collected. The cases of polymorphous adenocarcinoma and adenocarcinoma, not otherwise specified from January 2000 to January 2020 were reviewed to identify potential misdiagnosed MSA cases.
View Article and Find Full Text PDFNodular Fasciitis of the Buccal Mucosa with a Novel USP6 Gene Rearrangement: A Case Report and Review of the Literature.
Head Neck Pathol
August 2024
Department of Pathology, Rutgers New Jersey Medical School, 150 Bergen Street, Newark, NJ, 07103, USA.
Nodular fasciitis is a rare but benign fibroblastic proliferation that typically presents as a solitary lesion with rapid growth and variable mitotic activity. The lesions usually occur on the extremities and occasionally in the head/neck region. Involvement of the buccal mucosa is extremely rare with only few reports in the literature; in this case report, we describe a 41 year old female who presented with a 6-month history of a stable intraoral lump at the junction of the upper and lower lip.
View Article and Find Full Text PDFFine-needle aspiration cytology of retroperitoneal myoepithelial carcinoma: A rare encounter with diagnostic dilemmas.
Diagn Cytopathol
November 2024
Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Article Synopsis
- - Myoepithelial carcinoma (MC) is a rare tumor primarily found in salivary glands and occasionally in soft tissue, displaying both epithelial and smooth muscle characteristics, often affecting the extremities.
- - A case of retroperitoneal MC was accurately diagnosed using cytological findings combined with immunocytochemistry and fluorescence in situ hybridization to identify specific genetic rearrangements.
- - The study highlights the importance of recognizing the unique features of this tumor and using additional testing methods to address diagnostic challenges, as there are very few reported cases of soft tissue MC in medical literature.
Clear cell hidradenoma of the breast with MAML2 gene rearrangement.
Pathol Int
August 2024
Department of Pathology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- - Clear cell hidradenoma is a rare benign breast tumor with uncertain origins; this case involves a patient with a painless, hard mass in the left breast areola containing MAML2 gene rearrangement.
- - The tumor's structure was cystic and solid, featuring clear, epidermoid, and basaloid cells, with no signs of necrosis or mitotic activity, and exhibited specific immunohistochemical markers.
- - Distinct histological and immunophenotypic traits can differentiate it from other breast tumors, and the MAML2 gene alteration may indicate a unique genetic feature of this type of hidradenoma.
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